Medicine Research
Recent Submissions
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Quantitative prediction of toxicological points of departure using two-stage machine learning models: A new approach methodology (NAM) for chemical risk assessment
( Elsevier , 2025 , Article)Point of departure (POD) is a concept used in risk assessment to calculate the reference dose of exposure that is likely to have no appreciable risk on health. POD can be directly utilized from no observed adverse effect ... -
New world of big data—new challenges for evidence synthesis: impact of data duplication on estimates generated by meta-analyses and the development of a framework for its identification and management
( Elsevier , 2024 , Article)ObjectivesThe aim of this study was to highlight the effects of entering duplicated or overlapping data from published studies using the same data registries into a meta-analysis, including its identification and management ... -
The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
( Springer Nature , 2025 , Article)Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC ... -
Comparative Radiological Outcomes of Stand-alone Cage versus Cage and Plate in Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study.
( Thieme Medical and Scientific Publishers Pvt. Ltd. , 2024 , Article)Anterior cervical discectomy and fusion (ACDF) is one of the most commonly used techniques for neural decompression in degenerative cervical radiculopathy and cervical myelopathy. Controversies regarding the superiority ... -
Outcomes of intramedullary nailing versus plate fixation for humeral shaft fractures: a retrospective cohort study
( Springer Nature , 2025 , Article)BACKGROUND: Humeral shaft fractures account for 1-3% of all bone fractures. Conservative treatment often leads to complications such as non-union and shoulder stiffness. Surgical fixation with a dynamic compression plate ... -
Corrigendum to “Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management” [Pharmacological Reviews 77 (2025) 100008]
( Elsevier , 2025 , Article)Author Amirhossein Sahebkar’s last name was spelled incorrectly in the first version of this article. It has been updated. The authors apologize for this error. -
Exploring the medicinal potential of Citrus limon var. pompia camarda var. nova: From phytochemicals to therapeutic applications
( Elsevier , 2025 , Article Review)Citrus limon var. pompia Camarda var. nova, (CLP) an endemic citrus fruit from Sardinia, is emerging as a significant source of bioactive compounds with extensive health benefits. This comprehensive review examines the ... -
Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
(2025 , Article)A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated ... -
Evaluation of standards for sex estimation using measurements obtained from reconstructed computed tomography images of the femur of contemporary Black South Africans
( Springer Nature , 2025 , Article)Dimensions of the pelvic and skull bones are known to be sexually dimorphic in various population groups. The recovery of these bones is potentially beneficial in estimating the sex in forensic cases. Since both bones are ... -
Indications and clinical outcomes of percutaneous cholecystostomies in acute cholecystitis: a study from Qatar.
( BioMed Central , 2025 , Article)Acute cholecystitis (AC) is a prevalent condition in emergency departments (EDs). Standard care involves early laparoscopic cholecystectomy; however, in cases of delayed presentation, high surgical risk, or during situations ... -
Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar
( Elsevier , 2025 , Article)ObjectivesClostridioides difficile infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study ... -
Recent advances in stem cell-based therapies for type 1 diabetes: A glimpse into the future.
( The Association of Basic Medical Sciences , 2025 , Article Review)Type 1 diabetes mellitus (T1DM) is a serious, chronic metabolic and autoimmune disease that affects millions globally. While insulin administration remains the most effective treatment, it is not a cure. Long-term therapies, ... -
The epidemiology of antimicrobial resistant bacterial infection in Qatar: A systematic review and meta-analysis
( Elsevier , 2025 , Article)BackgroundAntimicrobial resistance (AMR) is the current silent pandemic responsible for approximately five million deaths annually. According to the WHO, antimicrobial resistance is one of the top global public health ... -
Balancing the Scalpel and the Heart: A Neurosurgeon's Guide to Empathy
( Elsevier , 2025 , Article Review)Empathy is a basic core human characteristic, the foundation for social relationships and interpersonal attachment. In medicine, particularly in neurosurgery, empathy goes beyond the concept of clinical neutrality and ... -
A novel deep learning framework for automatic scoring of PD-L1 expression in non-small cell lung cancer.
( The Association of Basic Medical Sciences , 2025 , Article)A critical predictive marker for anti-PD-1/PD-L1 therapy is programmed death-ligand 1 (PD-L1) expression, assessed by immunohistochemistry (IHC). This paper explores a novel automated framework using deep learning to ... -
Spontaneous Bacterial Peritonitis Beyond the Usual Suspects: Case Series of and With Comprehensive Literature Review.
( John Wiley & Sons, Ltd , 2025 , Article)While , , and species traditionally account for most cases of spontaneous bacterial peritonitis (SBP), atypical pathogens can be found. , typically known for causing gastroenteritis, rarely manifests as SBP, while , a ... -
Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
( Elsevier , 2025 , Article)BackgroundDespite a substantial reduction in the use of solid fuels for cooking worldwide, exposure to household air pollution (HAP) remains a leading global risk factor, contributing considerably to the burden of disease. ... -
A brief history of psychopharmacology
( Cambridge University Press , 2020 , Book chapter)The Oxford English Dictionary defines psychopharmacology as 'the scientific study of the effect of drugs on the mind and behaviour' (Oxford English Dictionary Online, 2018). The earliest reference to the term was in 1548 ... -
"Double-Lumen Valve-Controlled Intra-Operative Pyeloplasty Stent (VIPs)": A New Technology for Post-Pyeloplasty Stenting - Proof of Concept Study in a Preclinical Large Animal Model
( Dove Medical Press Ltd. , 2020 , Article)Background: Pyeloplasty is a common surgical operation with a high success rate. However, significant challenges are to be optimized in the design of stenting systems in order to improve perioperative monitoring of urine ... -
Missing something? A scoping review of venous thromboembolic events and their associations with bariatric surgery. Refining the evidence base
( Elsevier , 2020 , Article Review)Background: Venous thromboembolic events (VTE) post-bariatric surgery (BS) lead to morbidity and mortality. Methods: This scoping review assessed whether reported VTE post-BS could be under/over-estimated; suggested a ...
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