Medicine Research: المرسلات الحديثة
السجلات المعروضة 1121 -- 1140 من 1449
-
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
( Elsevier , 2020 , Article)ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ... -
The efficacy of colchicine in the management of coronavirus disease 2019: A protocol for systematic review and meta-analysis
( Lippincott, Williams & Wilkins , 2020 , Article)BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infection is a recently emerged viral infection causing predominantly mild upper respiratory symptoms. However, in some instances, it might result in ... -
Macrophage responses associated with COVID-19: A pharmacological perspective
( Elsevier , 2020 , Article)COVID-19 has caused worldwide death and economic destruction. The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great ... -
ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
( Springer , 2020 , Article)Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor and it is associated with poor survival. Integrin-linked kinase (ILK) is a serine/threonine protein pseudo-kinase that binds to the cytoplasmic domains ... -
High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
( Spandidos Publications , 2020 , Article)Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ... -
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
( MDPI , 2020 , Article)The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ... -
EMT Factors and Metabolic Pathways in Cancer.
( Frontiers Media , 2020 , Article)The epithelial-mesenchymal transition (EMT) represents a biological program during which epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is normally observed during organismal development, ... -
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
( International Institute of Anticancer Research , 2020 , Article)As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ... -
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
( Nature Research , 2020 , Article)The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ... -
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
( Public Library of Science , 2020 , Article)Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role ... -
High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes
( Nature Publishing Group , 2020 , Article)Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. We reported levels of serum protein glycation, oxidation and nitration and related hydrolysis products, glycation, ... -
Psychosocial Aspects of Female Breast Cancer in the Middle East and North Africa.
( MDPI , 2020 , Article)Breast cancer, the most common cancer among women in the Middle East and North Africa (MENA) region, is associated with social and psychological implications deriving from women's socio-cultural contexts. Examining 74 ... -
Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing
( Elsevier , 2021 , Article)© 2020 The Authors Management of chronic diabetic ulcers remains as a major challenge in healthcare which requires extensive multidisciplinary approaches to ensure wound protection, management of excess wound exudates and ... -
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
( Wiley , 2020 , Article)© 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ... -
Targeting DNA Repair Pathways in Hematological Malignancies.
( MDPI , 2020 , Article Review)DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple ... -
The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer.
( Taylor and Francis , 2020 , Article)High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. ... -
The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation
( Portland Press Ltd , 2017 , Article Review)At mammalian fertilisation, the fundamental stimulus that triggers oocyte (egg) activation and initiation of early embryonic development is an acute rise of the intracellular-free calcium (Ca2+) concentration inside the ... -
Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis.
( MDPI , 2020 , Article)Water-pipe smoking (WPS) is becoming the most popular form of tobacco use among the youth, especially in the Middle East, replacing cigarettes rapidly and becoming a major risk of tobacco addiction worldwide. Smoke from ... -
Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
( Frontiers Media , 2020 , Article)High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ...