Medicine Research: Recent submissions
Now showing items 741-760 of 1448
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Determinants of Atrial Fibrillation Development among Patients undergoing Ibrutinib Therapy
( Marshfield Clinic , 2022 , Article)Objective: Within the last decade, the use of ibrutinib, a first-generation, non-selective, irreversible Burton's tyrosine kinase inhibitor for the treatment of hematological malignancies has proven highly effective in ... -
Examining how meta-analytic methods perform
( Wiley , 2022 , Other)I read with interest the paper by Bramley et al.1 that concluded (regarding error estimation) that the IVhet method often outperforms the Henmi-copas (HC) method with fewer than 10 studies. They also concluded that the ... -
Redefining effect modification
( Wiley , 2022 , Article)The odds ratio (OR) has been misunderstood in evidence based medicine and clinical epidemiology. Currently, “noncollapsibility” is considered a problem with interpretation of the OR and it is thought that the OR is rarely ... -
Metabolic changes after nonsurgical fat removal: A dose response meta-analysis
( Elsevier , 2023 , Article Review)BackgroundObesity-induced insulin resistance leads to the metabolic syndrome. Both bariatric surgery and surgical fat removal have been shown to improve metabolic health, but the metabolic benefits of nonsurgical fat removal ... -
Perspectives of Persons With Type 2 Diabetes Toward Diabetes Self-Management: A Qualitative Study
( SAGE Publications , 2022 , Article)Background. The global increase in type 2 diabetes (T2D) poses a significant public health challenge worldwide. Due to the chronic and complex nature of the disease, management does not depend on pharmacotherapy alone; ... -
A Delphi consensus study introducing a Problem And attRibutes‐bAsed DIabetes self‐manaGeMent (PARADIGM) intervention for patients with type 2 diabetes
( Elsevier , 2022 , Article)AimEncouraging patients to improve their self-management behavior based on a strict definition of the intervention is important for a standardized delivery but, until recently, there was no consensus on the core attributes ... -
Diagnostic accuracy of multiplex nucleic acid amplification tests for Campylobacter infection: a systematic review and meta-analysis
( Taylor and Francis Group , 2022 , Article Review)Campylobacter infection is one of the most frequently reported foodborne diseases with approximately 230,000 and 1.5 million cases each year in Europe and the USA, respectively. Culture methods are the reference for the ... -
Metabolic changes after surgical fat removal: A dose–response meta-analysis
( Elsevier , 2023 , Article Review)BackgroundBariatric surgery averts obesity-induced insulin resistance and the metabolic syndrome. By contrast, surgical fat removal is considered merely an esthetic endeavor. The aim of this article was to establish whether ... -
Methodological quality assessment should move beyond design specificity.
( Lippincott, Williams & Wilkins , 2023 , Article)This study aimed to assess the utility of a unified tool (MASTER) for bias assessment against design-specific tools in terms of content and coverage. Each of the safeguards in the design-specific tools was compared and ... -
Duration of COVID-19 mRNA Vaccine Effectiveness against Severe Disease
( MDPI , 2022 , Article)Waning immunity following administration of mRNA-based COVID-19 vaccines remains a concern for many health systems. We undertook a study to determine if recent reports of waning for severe disease could have been attributed ... -
Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A metaanalysis
( Public Library of Science , 2022 , Article)Introduction Cystic fibrosis (CF) is a hereditary autosomal recessive disorder caused by a range of mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. This gene encodes the CFTR protein, which acts as a ... -
Likelihood ratio interpretation of the relative risk
( BMJ Publishing Group , 2022 , Article)Interpreting diagnostic test results in medicine The likelihood ratio (LR) is today commonly used in medicine for diagnostic inference. Historically, it was preceded by introduction, in 1966, of the predictive value ... -
Metabolic aspects of surgical subcutaneous fat removal: an umbrella review and implications for future research.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve ... -
Should studies with no events in both arms be excluded in evidence synthesis?
( Elsevier , 2022 , Article)ObjectivesIn safety assessment, studies with no events are a frequent occurrence when conducting meta-analyses. The current approach in meta-analysis is to exclude double-zero studies from the synthesis. In this study, we ... -
Does the Sex of the Firstborn Child Affect the Breast Cancer Risk and Survival: A Systematic Review and Meta-analysis of Over 1 Million Cases
( Galenos Yayinevi , 2022 , Article)Background: Reports on the risk and prognosis of breast cancer in relation to the sex of a child have been conflicting. Since medical sciences play an important role in informing sociocultural understandings of health and ... -
Data reproducibility issues and their potential impact on conclusions from evidence syntheses of randomized controlled trials in sleep medicine
( Elsevier , 2022 , Article)In this study, we examined the data reproducibility issues in systematic reviews in sleep medicine. We searched for systematic reviews of randomized controlled trials published in sleep medicine journals. The metadata in ... -
PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients
( Springer , 2022 , Article)Homozygous variants in the peptidyl-tRNA hydrolase 2 gene (PTRH2) cause infantile-onset multisystem neurologic, endocrine, and pancreatic disease. The objective is to delineate the mechanisms underlying the core cerebellar ... -
Clinicopathological and prognostic value of chemokine receptor CCR7 expression in head and neck squamous cell carcinoma: a systematic review and meta-analysis.
( Taylor and Francis Group , 2023 , Article)This study aimed to identify the clinicopathological characteristics and prognostic value of CC chemokine receptor 7 (CCR7) expression in patients with head and neck squamous cell carcinoma (HNSSC). The Preferred Reporting ... -
The Association between Early Opioids Prescribing and the Length of Disability in Acute Lower Back Pain: A Systematic Review and Narrative Synthesis
( MDPI , 2022 , Article Review)Background: There is conflicting evidence with respect to whether early opioid prescribing (EOP) within the first two weeks of acute Low Back Pain (LBP) onset is associated with the length of disability (LOD). The aim of ... -
The power of phytochemicals combination in cancer chemoprevention
( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...