Medicine Research: Recent submissions
Now showing items 1181-1200 of 1449
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EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
( American Chemical Society , 2020 , Article)Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ... -
Targeting HER2 expression in cancer: New drugs and new indications.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2020 , Article)Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. ... -
High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.
( MDPI , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
Identification of a Histone Deacetylase: Epigenetic Impact on Host Gene Expression.
( MDPI , 2020 , Article)Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. is a strict human pathogen that causes the sexually transmitted infection ... -
House dust mite-treated PAR2 over-expressor mouse: A novel model of atopic dermatitis
( Blackwell Publishing Ltd , 2019 , Article)Background Atopic dermatitis (AD) is a complex skin disease involving causative effects from both intrinsic and extrinsic sources. Murine models of the disease often fall short in one of these components and, as a result, ... -
A free terminal ileal perforation as the presenting sign of crohn’s disease in an adolescent female
( University Clinical Hospital Tuzla , 2020 , Article)The authors present a rare case of Aa free terminal ileal perforation as the presenting sign of Crohn's disease in an adolescent female. -
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
( MDPI , 2020 , Article)E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular ... -
Penile Degloving and Dorsal Dartos Flap Rotation Surgery in the Management of Severe Isolated Penile Torsion in a 6-Year-Old Boy.
( Karolinum Press , Charles University , 2020 , Article)Penile torsion is a rare congenital anomaly that is usually characterized by a counterclockwise rotation of the penile shaft or glans. Although several surgical techniques for its correction have been proposed, the consensus ... -
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
( hindawi , 2020 , Article)Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ... -
Comparative effectiveness and safety of direct-acting oral anticoagulants (DOACS) for the reduction of recurrent venous thromboembolism in cancer patients: A protocol for systematic review and network meta-analysis using a generalized pairwise modeling methodology.
( Lippincott, Williams & Wilkins , 2020 , Article)There has been a significant improvement in both our understanding and therapeutic choices available to clinicians for the management of cancer associated thrombosis (CAT). Even with the recent publication of a systematic ... -
Forensic utility of cranial measurements in stature reconstruction in South Africans of European descent.
( E Schweizerbart Science Publishers , 2020 , Article)The height of an individual (stature) is one of the biological profiles that is estimated as part of human identification process from various components of the human skeleton. The anatomical method is often used for this ... -
Morphometric profile of tendocalcaneus of South Africans of European ancestry using a cadaveric approach.
( Via Medica sp. z o.o. , 2020 , Article)Tendocalcaneus is a strong tendon that is vital for bipedalism in humans. Despite its tremendous strength, the tendocalcaneus is prone to damage and degeneration causing mobility problems and pain. Morphometric dimension ... -
A comparison of the direct and indirect methods of estimating skeletal height from tibial fragments in black South Africans.
( E Schweizerbart Science Publishers , 2020 , Article)The estimation of maximum bone length from its fragments is important in forensic anthropology as these length estimates can be used to estimate the total skeletal height (TSH), and thereby stature, of unknown skeletal ... -
Estimation of sex from metatarsals using discriminant function and logistic regression analyses
( Taylor & Francis , 2020 , Article)© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. South Africa has one of the highest crime rates in the world and the discovery of dismembered bodies for human identification ... -
2020 consensus guideline for optimal approach to the diagnosis and treatment of HER2-positive breast cancer in Bosnia and Herzegovina.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2020 , Article)The HERe2cure project, which involved a group of breast cancer experts, members of multidisciplinary tumor boards from healthcare institutions in Bosnia and Herzegovina, was initiated with the aim of defining an optimal ... -
Reading patterns of proteome damage by glycation, oxidation and nitration: quantitation by stable isotopic dilution analysis LC-MS/M
( Portland Press , 2020 , Article Review)Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a high sensitivity, high specificity multiplexed method for concurrent detection of adducts formed by protein glycation, oxidation and nitration, also ... -
Identifying essential competencies for medical students
( Emerald Group Publishing Ltd. , 2019 , Article)Purpose The purpose of this paper is to identify essential profession-related competencies, clinical knowledge and skills that medical students should develop in the early stages of their education for future professional ... -
Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets
( American Society for Clinical Investigation , 2019 , Article)Tumor-infiltrating lymphocytes (TILs) are widely associated with positive outcomes, yet carry key indicators of a systemic failed immune response against unresolved cancer. Cancer immunotherapies can reverse their tolerance ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ... -
The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression
( MDPI , 2015 , Article Review)Tumor-induced lymphangiogenesis facilitates breast cancer progression by generating new lymphatic vessels that serve as conduits for tumor dissemination to lymph nodes and beyond. Given the recent evidence suggesting the ...