Medicine Research: Recent submissions

Now showing items 541-560 of 1448

    • Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis 

      Halabi, Reem; Dakroub, Fatima; Haider, Mohammad Z.; Patel, Stuti; Amhaz, Nayef A.; ... more authors ( preprints , 2023 , Preprint)
      Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ...

    • Biological applications of imiquimod analogues: An update (Review) 

      Obeid, Joelle; Shaito, Abdullah; Hajj, Hiba El; Deleuze-Masquefa, Carine; Bonnet, Pierre Antoine; ... more authors ( Spandidos Publications , 2023 , Article Review)
      The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...

    • Biochemical and cellular basis of oxidative stress: Implications for disease onset 

      Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; ... more authors ( Wiley , 2023 , Article Review)
      Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...

    • Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 

      Rafael, Lozano; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M; ... more authors ( Elsevier , 2020 , Article)
      Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority ...

    • Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 

      Haidong, Wang; Abbas, Kaja M; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; ... more authors ( Elsevier , 2020 , Article)
      Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, ...

    • Five insights from the Global Burden of Disease Study 2019 

      Christopher J L, Murray; Abbafati, Cristiana; Abbas, Kaja M; Abbasi, Mohammad; Abbasi-Kangevari, Mohsen; ... more authors ( Elsevier , 2020 , Article Review)
      The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system ...

    • The power of genetic diversity in genome-wide association studies of lipids 

      Graham, Sarah E.; Clarke, Shoa L.; Wu, Kuan Han H.; Kanoni, Stavroula; Zajac, Greg J.M.; ... more authors ( Nature Research , 2021 , Article)
      Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ...

    • A longitudinal analysis of the effect of maternal region-of-birth on transitions in children's bodyweight status from early childhood to late adolescence in Australia: A population-based cohort study 

      Hartono, Susan; Cochrane, Tom; Niyonsenga, Theo; Kinfu, Yohannes ( Elsevier , 2021 , Article)
      Although 49% of Australian residents have at least one overseas-born parent, little is known about children's longitudinal bodyweight transitions among the migrant population. This study examines the net associations between ...

    • Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs 

      Toth, Krisztian; Nagi, Karim; Slosky, Lauren M.; Rochelle, Lauren; Ray, Caroline; ... more authors ( American Chemical Society , 2019 , Article)
      G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement ...

    • Pravastatin plus L-arginine prevents adverse pregnancy outcomes in women with uteroplacental vascular dysfunction 

      Jurisic, Aleksandar; Jurisic, Zaklina; Lefkou, Eleftheria; Girardi, Guillermina ( Elsevier , 2021 , Article)
      Background: Uteroplacental vascular dysfunction, characterized by diminished uterine artery (UtA) blood flow in the second trimester is a clinically useful predictor of the further development of preeclampsia, fetal growth ...

    • Erratum: Author Correction: Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer (NPJ systems biology and applications (2020) 6 1 (23)) 

      Mastrogamvraki, Natalia; Zaravinos, Apostolos ( NLM (Medline) , 2020 , Other)
      In the original version of this Article, the wrong images were supplied for Figures 7 and 10. This has now been corrected in both the HTML and PDF versions of the Article.

    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; ... more authors ( Nature Research , 2022 , Article)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...

    • KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals 

      Thillaiappan, Nagendra Babu; Smith, Holly A.; Atakpa-Adaji, Peace; Taylor, Colin W. ( Nature Research , 2021 , Article)
      Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile ...

    • COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response 

      Souchelnytskyi, Serhiy; Nera, Andriy; Souchelnytskyi, Nazariy ( Nature Research , 2021 , Article)
      Clinical reports show that the management of cancer patients infected with SARS-CoV-2 requires modifications. Understanding of cancer-relevant mechanisms engaged by the virus is essential for the evidence-based management ...

    • Undergraduate nursing and medical students' perceptions of food security and access to healthy food in Qatar: a photovoice study 

      Al-Hamad, Areej; MacNevin, Shannan; Daher-Nashif, Suhad ( Cambridge University Press , 2022 , Article)
      The present study explored nursing and medical students' perceptions of food security, their access to healthy food and the circumstances that affect their access to healthy food in Qatar. The photovoice method was adopted ...

    • Identification of potential transcription factors that enhance human iPSC generation 

      Swaidan, Nuha T.; Salloum-Asfar, Salam; Palangi, Freshteh; Errafii, Khaoula; Soliman, Nada H.; ... more authors ( Springer Nature , 2020 , Article)
      Although many factors have been identified and used to enhance the iPSC reprogramming process, its efficiency remains quite low. In addition, reprogramming efficacy has been evidenced to be affected by disease mutations ...

    • Severe immune thrombocytopenia following MMR vaccination with rapid recovery: A case report and review of literature 

      Akbik, Majd; Naddeh, Dima; Ashour, Anas A.; Ashour, Azzam ( Dove Medical Press , 2020 , Article)
      Immune thrombocytopenia (ITP) is an autoimmune disease that occurs following viral illnesses and may also infrequently occur after measles, mumps, and rubella (MMR) vaccination. ITP typically presents with the sudden ...

    • Brief psychotic disorder associated with quarantine and mild COVID-19 

      Haddad, Peter M.; Al Abdulla, Majid; Latoo, Javed; Iqbal, Yousaf ( BMJ Publishing Group , 2020 , Article)
      A 30-year-old man with no significant previous or family psychiatric history became severely anxious about his health after a positive COVID-19 test. Physical symptoms of COVID-19 were mild, with no evidence of hypoxia or ...

    • The Net Clinical Benefit of Rivaroxaban Compared to Low-Molecular-Weight Heparin in the Treatment of Cancer-Associated Thrombosis: Systematic Review and Meta-Analysis 

      Mohamed, Mouhand F.H.; ElShafei, Mohamad Nabil; Ahmed, Mohamed Badie; Abdalla, Lina O.; Ahmed, Israa; ... more authors ( SAGE , 2021 , Article)
      Cancer-associated thrombosis (CAT) carries significant morbidity and mortality. Low-molecular-weight heparin (LMWH) remains the standard of care, with recent systematic studies suggesting the efficacy and safety of rivaroxaban ...

    • Pharmacological and antioxidant activities of rhus coriaria l. (sumac) 

      Alsamri, Halima; Athamneh, Khawlah; Pintus, Gianfranco; Eid, Ali H.; Iratni, Rabah ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)
      Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ...