Titanium-Containing Silicate-Based Sol-Gel Bioactive Glass: Development, Characterization, and Applications
Author | Smith S. |
Author | Elkashty O. |
Author | Tamimi F. |
Author | Tran S.D. |
Author | Cerruti M. |
Available date | 2022-05-31T19:01:18Z |
Publication Date | 2021 |
Publication Name | Langmuir |
Resource | Scopus |
Identifier | http://dx.doi.org/10.1021/acs.langmuir.1c01593 |
Abstract | Bioactive glasses are surface-reactive glasses that, when placed in physiological fluid, undergo a transformation from glass to hydroxyapatite. Doping the bioactive glass with metallic ions can impart desirable and unique properties that are not inherent to natural hydroxyapatite. Once such ion is titanium. Titanium exists in trace amounts in native dental enamel, and its presence has been correlated with increased tooth hardness and brightness, both desirable clinical properties. Synthetic titanium-substituted hydroxyapatite exhibits better mechanical and antibacterial properties and demonstrates potential for an improved cellular response when compared to unmodified hydroxyapatite with applications in the broader field of bone tissue engineering. In this work, we use the sol-gel method to synthesize a titanium-containing silicate-based bioactive glass aimed at generating titanium-substituted hydroxyapatite on the glass surface upon immersion in body fluid. Titanium is homogeneously distributed throughout our glass, which keeps its amorphous nature. After 14 days of immersion in simulated body fluid, the glass forms a titanium-substituted hydroxyapatite on its surface. Enamel surfaces treated with the titanium-containing glass show significantly increased microhardness compared to enamel surfaces treated with a control glass, confirming the potential for the proposed glass in enamel remineralization. We also show that the presence of titanium in the glass promotes cell differentiation toward bone formation, suggesting further applications for this material in the broader field of bone tissue engineering. |
Language | en |
Publisher | American Chemical Society |
Subject | Bioactive glass Body fluids Bone Cell engineering Enamels Scanning electron microscopy Silicates Sol-gel process Sol-gels Tissue engineering Titanium compounds Bone tissue engineering Enamel surface Physiological fluids Property Reactive glass Sol'gel Substituted hydroxyapatites Surface treated Titania Titanium containing Hydroxyapatite glass hydroxyapatite silicate titanium bone development Durapatite Glass Osteogenesis Silicates Titanium |
Type | Article |
Pagination | 14243-14253 |
Issue Number | 49 |
Volume Number | 37 |
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Dental Medicine Research [282 items ]