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AuthorMoussa H.
AuthorEl Hadad A.
AuthorSarrigiannidis S.
AuthorSaad A.
AuthorWang M.
AuthorTaqi D.
AuthorAl-Hamed F.S.
AuthorSalmer�n-S�nchez M.
AuthorCerruti M.
AuthorTamimi F.
Available date2022-05-31T19:01:19Z
Publication Date2021
Publication NameMaterials Science and Engineering C
ResourceScopus
Identifierhttp://dx.doi.org/10.1016/j.msec.2021.112205
URIhttp://hdl.handle.net/10576/31815
AbstractThe ideal bone substitute material should be mechanically strong, biocompatible with a resorption rate matching the rate of new bone formation. Brushite (dicalcium phosphate dihydrate) cement is a promising bone substitute material but with limited resorbability and mechanical properties. To improve the resorbability and mechanical performance of brushite cements, we incorporated gypsum (calcium sulfate dihydrate) and diazonium-treated polyglactin fibers which are well-known for their biocompatibility and bioresorbability. Here we show that by combining brushite and gypsum, we were able to fabricate biocompatible composite cements with high fracture toughness (0.47 MPa�m1/2) and a resorption rate that matched the rate of new bone formation. Adding functionalized polyglactin fibers to this composite cement further improved the fracture toughness up to 1.00 MPa�m1/2. XPS and SEM revealed that the improvement in fracture toughness is due to the strong interfacial bonding between the functionalized fibers and the cement matrix. This study shows that adding gypsum and functionalized polyglactin fibers to brushite cements results in composite biomaterials that combine high fracture toughness, resorbability, and biocompatibility, and have great potential for bone regeneration.
Languageen
PublisherElsevier Ltd
SubjectBiocompatibility
Calcium compounds
Cements
Fiber bonding
Fracture toughness
Gypsum
Bone formation
Bone substitute materials
Brushite
Diazonia treatment
Functionalized
Gypsum cement
Polyglactin
Polyglactin fiber
Resorbability
Resorption rates
Fibers
bone cement
calcium phosphate
calcium phosphate, dibasic, dihydrate
calcium sulfate
materials testing
Bone Cements
Calcium Phosphates
Calcium Sulfate
Materials Testing
TitleHigh toughness resorbable brushite-gypsum fiber-reinforced cements
TypeArticle
Volume Number127
dc.accessType Abstract Only


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