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المؤلفMoussa H.
المؤلفEl Hadad A.
المؤلفSarrigiannidis S.
المؤلفSaad A.
المؤلفWang M.
المؤلفTaqi D.
المؤلفAl-Hamed F.S.
المؤلفSalmer�n-S�nchez M.
المؤلفCerruti M.
المؤلفTamimi F.
تاريخ الإتاحة2022-05-31T19:01:19Z
تاريخ النشر2021
اسم المنشورMaterials Science and Engineering C
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.msec.2021.112205
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31815
الملخصThe ideal bone substitute material should be mechanically strong, biocompatible with a resorption rate matching the rate of new bone formation. Brushite (dicalcium phosphate dihydrate) cement is a promising bone substitute material but with limited resorbability and mechanical properties. To improve the resorbability and mechanical performance of brushite cements, we incorporated gypsum (calcium sulfate dihydrate) and diazonium-treated polyglactin fibers which are well-known for their biocompatibility and bioresorbability. Here we show that by combining brushite and gypsum, we were able to fabricate biocompatible composite cements with high fracture toughness (0.47 MPa�m1/2) and a resorption rate that matched the rate of new bone formation. Adding functionalized polyglactin fibers to this composite cement further improved the fracture toughness up to 1.00 MPa�m1/2. XPS and SEM revealed that the improvement in fracture toughness is due to the strong interfacial bonding between the functionalized fibers and the cement matrix. This study shows that adding gypsum and functionalized polyglactin fibers to brushite cements results in composite biomaterials that combine high fracture toughness, resorbability, and biocompatibility, and have great potential for bone regeneration.
اللغةen
الناشرElsevier Ltd
الموضوعBiocompatibility
Calcium compounds
Cements
Fiber bonding
Fracture toughness
Gypsum
Bone formation
Bone substitute materials
Brushite
Diazonia treatment
Functionalized
Gypsum cement
Polyglactin
Polyglactin fiber
Resorbability
Resorption rates
Fibers
bone cement
calcium phosphate
calcium phosphate, dibasic, dihydrate
calcium sulfate
materials testing
Bone Cements
Calcium Phosphates
Calcium Sulfate
Materials Testing
العنوانHigh toughness resorbable brushite-gypsum fiber-reinforced cements
النوعArticle
رقم المجلد127
dc.accessType Abstract Only


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