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المؤلفShraim B.A.
المؤلفMoursi M.O.
المؤلفBenter I.F.
المؤلفHabib A.M.
المؤلفAkhtar S.
تاريخ الإتاحة2022-05-31T19:01:28Z
تاريخ النشر2021
اسم المنشورFrontiers in Pharmacology
المصدرScopus
المعرّفhttp://dx.doi.org/10.3389/fphar.2021.701390
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85112695710&doi=http://dx.doi.org/10.3389%2ffphar.2021.701390&partnerID=40&md5=8b7dd4b5f5972579d56faecbb97ecf5d
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31871
الملخصDiabetes mellitus is a major debilitating disease whose global incidence is progressively increasing with currently over 463 million adult sufferers and this figure will likely reach over 700 million by the year 2045. It is the complications of diabetes such as cardiovascular, renal, neuronal and ocular dysfunction that lead to increased patient morbidity and mortality. Of these, cardiovascular complications that can result in stroke and cardiomyopathies are 2- to 5-fold more likely in diabetes but the underlying mechanisms involved in their development are not fully understood. Emerging research suggests that members of the Epidermal Growth Factor Receptor (EGFR/ErbB/HER) family of tyrosine kinases can have a dual role in that they are beneficially required for normal development and physiological functioning of the cardiovascular system (CVS) as well as in salvage pathways following acute cardiac ischemia/reperfusion injury but their chronic dysregulation may also be intricately involved in mediating diabetes-induced cardiovascular pathologies. Here we review the evidence for EGFR/ErbB/HER receptors in mediating these dual roles in the CVS and also discuss their potential interplay with the Renin-Angiotensin-Aldosterone System heptapeptide, Angiotensin-(1-7), as well the arachidonic acid metabolite, 20-HETE (20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid). A greater understanding of the multi-faceted roles of EGFR/ErbB/HER family of tyrosine kinases and their interplay with other key modulators of cardiovascular function could facilitate the development of novel therapeutic strategies for treating diabetes-induced cardiovascular complications.
اللغةen
الناشرFrontiers Media S.A.
الموضوع2 morpholino 8 phenylchromone
20 hydroxyicosatetraenoic acid
4 (3 chloroanilino) 6,7 dimethoxyquinazoline
advanced glycation end product
aldosterone
angiotensin
angiotensin[1-7]
diacylglycerol
endothelial nitric oxide synthase
epidermal growth factor receptor
epidermal growth factor receptor 2
epidermal growth factor receptor 3
epidermal growth factor receptor 4
epigallocatechin gallate
G protein coupled receptor
G protein coupled receptor 75
gefitinib
glucose
glutathione reductase
immunoglobulin enhancer binding protein
Janus kinase
lapatinib
mammalian target of rapamycin
mitogen activated protein kinase 1
mitogen activated protein kinase 3
mitogen activated protein kinase p38
n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino]methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide
phosphatidylinositol 3 kinase
phospholipase C gamma1
protein kinase B
protein kinase C
reduced nicotinamide adenine dinucleotide phosphate oxidase
renin
STAT protein
thioredoxin reductase
transcription factor FKHRL1
unclassified drug
antiinflammatory activity
antioxidant activity
cardiovascular disease
cardiovascular function
cerebrovascular accident
diabetic angiopathy
diabetic cardiomyopathy
drug research
endothelial dysfunction
human
hyperglycemia
insulin dependent diabetes mellitus
medical research
myocardial ischemia reperfusion injury
non insulin dependent diabetes mellitus
nonhuman
oxidative stress
pathophysiology
protein family
protein function
renin angiotensin aldosterone system
Review
العنوانThe Role of Epidermal Growth Factor Receptor Family of Receptor Tyrosine Kinases in Mediating Diabetes-Induced Cardiovascular Complications
النوعArticle
رقم المجلد12
dc.accessType Abstract Only


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