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Quantitative prediction of toxicological points of departure using two-stage machine learning models: A new approach methodology (NAM) for chemical risk assessment
( Elsevier , 2025 , Article)Point of departure (POD) is a concept used in risk assessment to calculate the reference dose of exposure that is likely to have no appreciable risk on health. POD can be directly utilized from no observed adverse effect ... -
Young bone marrow transplantation delays bone aging in old mice
( Elsevier , 2025 , Article)Recent discoveries have shown that systemic manipulations, such as parabiosis, blood exchange, and young plasma transfer, can counteract many hallmarks of aging. This rejuvenation effect has been attributed to circulatory ... -
Hepatitis C virus transmission among people who inject drugs in the Middle East and North Africa: mathematical modeling analyses of incidence and intervention impact
( Elsevier , 2025 , Article)BackgroundThe Middle East and North Africa (MENA) region is the most affected by hepatitis C virus (HCV) infection globally. This study aimed to estimate HCV incidence among people who inject drugs (PWID) in MENA and ... -
New world of big data—new challenges for evidence synthesis: impact of data duplication on estimates generated by meta-analyses and the development of a framework for its identification and management
( Elsevier , 2024 , Article)ObjectivesThe aim of this study was to highlight the effects of entering duplicated or overlapping data from published studies using the same data registries into a meta-analysis, including its identification and management ... -
Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis
( Elsevier , 2025 , Article)BackgroundSurgical site infections (SSIs) are the most common postoperative complications after cesarean section (CS), with increased mortality, prolonged hospital stays, and increased healthcare costs. ObjectiveTo ... -
Oral Cancer Knowledge and Screening Practices Among Dental Professionals in Yemen: a Web-Based Survey
( Elsevier , 2025 , Article)BackgroundGood knowledge and screening practices of dental professionals for oral cancer (OC) will inevitably improve its prognosis. The present study sought to evaluate OC knowledge and practices among dental professionals ... -
The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
( Springer Nature , 2025 , Article)Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC ... -
Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials
( Springer Nature , 2025 , Article)Background: Recent guidelines recommend the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors (SGLT2i) in patients suffering from cardiorenal diseases. However, the safety and efficacy of SGLT2i in older adults ... -
Dihydropyrimidine Dehydrogenase Deficiency (DPYD) Genotyping-Guided Fluoropyrimidine-Based Adjuvant Chemotherapy for Breast Cancer. A Cost-Effectiveness Analysis
( Springer Nature , 2025 , Article)Background and Objective: While standard doses of adjuvant fluoropyrimidine-based chemotherapies are generally safe for most patients, the risk of severe adverse drug reactions (ADRs) is increased for those with dihydropyrimidine ... -
Development of a peak insertion torque prediction model for parallel-walled dental implants
( Elsevier , 2025 , Article)Implant peak insertion torque is a commonly used indication of primary stability that dentists rely on to make clinical decisions. The aim of this manuscript is to model the peak torque required for dental implant insertion ... -
Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
( Elsevier , 2025 , Article)BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. Diagnosing syphilis is challenging due to its often-asymptomatic ... -
Prevalence and associated factors of oral pigmented lesions among Yemeni dental patients: a large cross-sectional study.
( BioMed Central , 2025 , Article)The literature is scarce and inconsistent regarding the prevalence, types, and risk factors of oral pigmented lesions (OPL). The present study investigated the prevalence, types, and distribution of OPL, as well as their ... -
Enablers and barriers to community pharmacists' readiness to implement deprescribing of inappropriate medications for older adults in Qatar
( Public Library of Science , 2025 , Article)There is paucity of studies focused on the enablers and barriers to community pharmacists’ readiness to deprescribe inappropriate medications for older adults in developing settings. The current study assessed the enablers ... -
Comparative Radiological Outcomes of Stand-alone Cage versus Cage and Plate in Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study.
( Thieme Medical and Scientific Publishers Pvt. Ltd. , 2024 , Article)Anterior cervical discectomy and fusion (ACDF) is one of the most commonly used techniques for neural decompression in degenerative cervical radiculopathy and cervical myelopathy. Controversies regarding the superiority ... -
Outcomes of intramedullary nailing versus plate fixation for humeral shaft fractures: a retrospective cohort study
( Springer Nature , 2025 , Article)BACKGROUND: Humeral shaft fractures account for 1-3% of all bone fractures. Conservative treatment often leads to complications such as non-union and shoulder stiffness. Surgical fixation with a dynamic compression plate ... -
Corrigendum to “Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management” [Pharmacological Reviews 77 (2025) 100008]
( Elsevier , 2025 , Article)Author Amirhossein Sahebkar’s last name was spelled incorrectly in the first version of this article. It has been updated. The authors apologize for this error. -
Exploring the medicinal potential of Citrus limon var. pompia camarda var. nova: From phytochemicals to therapeutic applications
( Elsevier , 2025 , Article Review)Citrus limon var. pompia Camarda var. nova, (CLP) an endemic citrus fruit from Sardinia, is emerging as a significant source of bioactive compounds with extensive health benefits. This comprehensive review examines the ... -
Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
(2025 , Article)A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated ... -
Evaluation of standards for sex estimation using measurements obtained from reconstructed computed tomography images of the femur of contemporary Black South Africans
( Springer Nature , 2025 , Article)Dimensions of the pelvic and skull bones are known to be sexually dimorphic in various population groups. The recovery of these bones is potentially beneficial in estimating the sex in forensic cases. Since both bones are ... -
Prognostic Models of Mortality Following First-Ever Acute Ischemic Stroke: A Population-Based Retrospective Cohort Study
( John Wiley & Sons , 2025 , Article)Background and Aims: There is a lack of population-based studies focusing on guideline-based prognostic models for stroke. This study aimed to develop and validate a prognostic model that predicts mortality following a ...
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