Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties
المؤلف | Mesmar, Joelle |
المؤلف | Abdallah, Rola |
المؤلف | Badran, Adnan |
المؤلف | Maresca, Marc |
المؤلف | Shaito, Abdullah |
المؤلف | Baydoun, Elias |
تاريخ الإتاحة | 2022-08-23T05:21:37Z |
تاريخ النشر | 2022-07-01 |
اسم المنشور | Molecules |
المعرّف | http://dx.doi.org/10.3390/molecules27134240 |
الاقتباس | Mesmar J, Abdallah R, Badran A, Maresca M, Shaito A, Baydoun E. Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties. Molecules. 2022 Jun 30;27(13):4240. doi: 10.3390/molecules27134240. |
الملخص | Ziziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: To gather the current knowledge related to the medicinal characteristics of Z. nummularia. Specifically, its phytochemical contents and pharmacological activities in the treatment of various diseases such as cancer, diabetes, and cardiovascular diseases, are discussed. Methods: Major scientific literature databases, including PubMed, Scopus, ScienceDirect, SciFinder, Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, Henriette′s Herbal Homepage, Dr. Duke′s Phytochemical and Ethnobotanical Databases, were searched to retrieve articles related to the review subject. General web searches using Google and Google scholar were also utilized. The search period covered articles published between 1980 and the end of October 2021.The search used the keywords ‘Ziziphus nummularia’, AND (‘phytochemical content’, ‘pharmacological properties, or activities, or effects, or roles’, ‘anti-inflammatory’, ‘anti-drought’, ‘anti-thermal’, ‘anthelmintic’, ‘antidiabetic’,’ anticancer’, ‘anticholinesterase’, ‘antimicrobial’, ‘sedative’, ‘antipyretic’, ‘analgesic’, or ‘gastrointestinal’). Results: This plant is rich in characteristic alkaloids, especially cyclopeptide alkaloids such as nummularine-M. Other phytochemicals, including flavonoids, saponins, glycosides, tannins, and phenolic compounds, are also present. These phytochemicals are responsible for the reported pharmacological properties of Z. nummularia, including anti-inflammatory, antioxidant, antimicrobial, anthelmintic, antidiabetic, anticancer, analgesic, and gastrointestinal activities. In addition, Z. nummularia has anti-drought and anti-thermal characteristics. Conclusion: Research into the phytochemical and pharmacological properties of Z. nummularia has demonstrated that this plant is a rich source of novel bioactive compounds. So far, Z. nummularia has shown a varied pharmacological profile (antioxidant, anticancer, anti-inflammatory, and cardioprotective), warranting further research to uncover the therapeutic potential of the bioactives of this plant. Taken together, Z. nummularia may represent a new potential target for the discovery of new drug leads. |
راعي المشروع | The authors would like to thank the URB of the American University of Beirut and the University of Petra for their funding |
اللغة | en |
الناشر | MDPI |
الموضوع | anti-inflammatory antioxidant cyclopeptide alkaloids nummularine-M phytochemicals Ziziphus nummularia |
النوع | Article Review |
رقم العدد | 13 |
رقم المجلد | 27 |
ESSN | 1420-3049 |
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