Markers associated with covid-19 susceptibility, resistance, and severity
المؤلف | Fakhroo, A.D. |
المؤلف | Fakhroo, Aisha D. |
المؤلف | Al Thani, Asmaa A. |
المؤلف | Yassine, Hadi M. |
تاريخ الإتاحة | 2022-09-14T11:42:50Z |
تاريخ النشر | 2021-01-01 |
اسم المنشور | Viruses |
المعرّف | http://dx.doi.org/10.3390/v13010045 |
الاقتباس | Fakhroo, A. D., Al Thani, A. A., & Yassine, H. M. (2020). Markers associated with COVID-19 susceptibility, resistance, and severity. Viruses, 13(1), 45. |
الملخص | In December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity. |
اللغة | en |
الناشر | MDPI AG |
الموضوع | COVID-19 Pathogenesis Resistance SARS Susceptibility |
النوع | Article Review |
رقم العدد | 1 |
رقم المجلد | 13 |
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