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AuthorFakhroo, A.D.
AuthorFakhroo, Aisha D.
AuthorAl Thani, Asmaa A.
AuthorYassine, Hadi M.
Available date2022-09-14T11:42:50Z
Publication Date2021-01-01
Publication NameViruses
Identifierhttp://dx.doi.org/10.3390/v13010045
CitationFakhroo, A. D., Al Thani, A. A., & Yassine, H. M. (2020). Markers associated with COVID-19 susceptibility, resistance, and severity. Viruses, 13(1), 45.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099332051&origin=inward
URIhttp://hdl.handle.net/10576/34027
AbstractIn December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity.
Languageen
PublisherMDPI AG
SubjectCOVID-19
Pathogenesis
Resistance
SARS
Susceptibility
TitleMarkers associated with covid-19 susceptibility, resistance, and severity
TypeArticle Review
Issue Number1
Volume Number13
dc.accessType Open Access


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