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المؤلفAgostinis, Chiara
المؤلفToffoli, Miriam
المؤلفSpazzapan, Mariagiulia
المؤلفBalduit, Andrea
المؤلفZito, Gabriella
المؤلفMangogna, Alessandro
المؤلفZupin, Luisa
المؤلفSalviato, Tiziana
المؤلفMaiocchi, Serena
المؤلفRomano, Federico
المؤلفCrovella, Sergio
المؤلفFontana, Francesco
المؤلفBraga, Luca
المؤلفConfalonieri, Marco
المؤلفRicci, Giuseppe
المؤلفKishore, Uday
المؤلفBulla, Roberta
تاريخ الإتاحة2022-10-24T09:00:46Z
تاريخ النشر2022-09-13
اسم المنشورFrontiers in Immunology
المعرّفhttp://dx.doi.org/10.3389/fimmu.2022.957224
الاقتباسAgostinis C, Toffoli M, Spazzapan M, Balduit A, Zito G, Mangogna A, Zupin L, Salviato T, Maiocchi S, Romano F, Crovella S, Fontana F, Braga L, Confalonieri M, Ricci G, Kishore U and Bulla R (2022) SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability. Frontiers in immunology. 13:957224. doi: 10.3389/fimmu.2022.957224
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138867288&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/35352
الملخصSARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection impacts pregnant mothers is still being worked out due to evidence of vertical transmission of the SARS-CoV-2, and higher incidence of pre-eclampsia, preterm birth, caesarian section, and fetal mortality. In this study, we assessed the levels of the three main receptors of SARS-CoV-2 (ACE2, TMPRSS2 and CD147) in placentae derived from SARS-CoV-2 positive and negative mothers. Moreover, we measured the effects of Spike protein on placental cell lines, in addition to their susceptibility to infection. SARS-CoV-2 negative placentae showed elevated levels of CD147 and considerably low amount of TMPRSS2, making them non-permissive to infection. SARS-CoV-2 presence upregulated TMPRSS2 expression in syncytiotrophoblast and cytotrophoblast cells, thereby rendering them amenable to infection. The non-permissiveness of placental cells can be due to their less fusogenicity due to infection. We also found that Spike protein was capable of inducing pro-inflammatory cytokine production, syncytiotrophoblast apoptosis and increased vascular permeability. These events can elicit pre-eclampsia-like syndrome that marks a high percentage of pregnancies when mothers are infected with SARS-CoV-2. Our study raises important points relevant to SARS-CoV-2 mediated adverse pregnancy outcomes.
راعي المشروعFerring COVID-19 Investigational Grant (GRAVISAR to RB)
اللغةen
الناشرFrontiers Media
الموضوعACE2
CD147
pregnancy
SARS-CoV-2
TMPRSS2
العنوانSARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability
النوعArticle
الصفحات1-20
رقم المجلد13
ESSN1664-3224
dc.accessType Open Access


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