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AuthorAlser, Maha
AuthorElrayess, Mohamed A
Available date2022-11-16T06:42:32Z
Publication Date2022-10-31
Publication NameIJERPH
Identifierhttp://dx.doi.org/10.3390/ijerph192114251
CitationAlser, M.; Elrayess, M.A. From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance. Int. J. Environ. Res. Public Health 2022, 19, 14251. https://doi.org/10.3390/ijerph192114251
URIhttp://hdl.handle.net/10576/36472
AbstractType 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a proportion of obese individuals who express a metabolically healthy profile, whereas some lean individuals could develop metabolic disorders. To study obesity as a risk factor, body fat distribution needs to be considered rather than crude body weight. Different individuals' bodies favor storing fat in different depots; some tend to accumulate more fat in the visceral depot, while others tend to store it in the femoral depot. This tendency relies on different factors, including genetic background and lifestyle. Consuming some types of medications can cause a shift in this tendency, leading to fat redistribution. Fat distribution plays an important role in the progression of risk of insulin resistance (IR). Apple-shaped individuals with enhanced abdominal obesity have a higher risk of IR compared to BMI-matched pear-shaped individuals, who store their fat in the gluteal-femoral depots. This is related to the different adipose tissue physiology between these two depots. In this review, we will summarize the recent evidence highlighting the underlying protective mechanisms in gluteal-femoral subcutaneous adipose tissues compared to those associated with abdominal adipose tissue, and we will revise the recent evidence showing antidiabetic drugs that impact fat distribution as they manage the T2D condition.
SponsorThis research was funded by the Qatar National Research Fund (QNRF), grant number NPRP13S-1230-190008.
Languageen
PublisherMDPI
Subjectabdominal subcutaneous fat
body fat composition
diabetes
fat depot
gluteal-femoral subcutaneous fat
obesity
TitleFrom an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance.
TypeArticle Review
Issue Number21
Volume Number19
ESSN1660-4601
dc.accessType Open Access


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