Pharmacoeconomic analysis of voriconazole vs. caspofungin in the empirical antifungal therapy of febrile neutropenia in Australia
المؤلف | Al-Badriyeh, Daoud |
المؤلف | Liew, Danny |
المؤلف | Stewart, Kay |
المؤلف | Kong, David C. M. |
تاريخ الإتاحة | 2015-11-05T10:11:50Z |
تاريخ النشر | 2012 |
اسم المنشور | Mycoses |
المصدر | Wiley Online library |
الاقتباس | Al-Badriyeh, D., Liew, D., Stewart, K. and Kong, D. C. M. (2012), Pharmacoeconomic analysis of voriconazole vs. caspofungin in the empirical antifungal therapy of febrile neutropenia in Australia. Mycoses, 55: 244–256. |
الرقم المعياري الدولي للكتاب | 1439-0507 |
الملخص | In two major clinical trials, voriconazole and caspofungin were recommended as alternatives to liposomal amphotericin B for empirical use in febrile neutropenia. This study investigated the health economic impact of using voriconazole vs. caspofungin in patients with febrile neutropenia. A decision analytic model was developed to measure downstream consequences of empirical antifungal therapy. Clinical outcomes measured were success, breakthrough infection, persistent base-line infection, persistent fever, premature discontinuation and death. Treatment transition probabilities and patterns were directly derived from data in two relevant randomised controlled trials. Resource use was estimated using an expert clinical panel. Cost inputs were obtained from latest Australian sources. The analysis adopted the perspective of the Australian hospital system. The use of caspofungin led to a lower expected mean cost per patient than voriconazole (AU$40 558 vs. AU$41 356), with a net cost saving of AU$798 (1.9%) per patient. Results were most sensitive to the duration of therapy and the alternative therapy used post-discontinuation. In uncertainty analysis, the cost associated with caspofungin is less than that with voriconazole in 65.5% of cases. This is the first economic evaluation of voriconazole vs. caspofungin for empirical therapy. Caspofungin appears to have a higher probability of having cost-savings than voriconazole for empirical therapy. The difference between the two medications does not seem to be statistically significant however. |
اللغة | en |
الناشر | Blackwell Publishing Ltd |
الموضوع | Cost-benefit economic model empiric voriconazole caspofungin |
النوع | Article |
رقم العدد | 3 |
رقم المجلد | 55 |
الملفات في هذه التسجيلة
الملفات | الحجم | الصيغة | العرض |
---|---|---|---|
لا توجد ملفات لها صلة بهذه التسجيلة. |
هذه التسجيلة تظهر في المجموعات التالية
-
أبحاث الصيدلة [1243 items ]