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AuthorMousa, Hanaa
AuthorElrayess, Mohamed A.
AuthorDiboun, Ilhame
AuthorJackson, Simon K.
AuthorZughaier, Susu M.
Available date2023-01-15T04:54:55Z
Publication Date2022-08-01
Publication NameMetabolites
Identifierhttp://dx.doi.org/10.3390/metabo12080771
CitationMousa, H.; Elrayess, M.A.; Diboun, I.; Jackson, S.K.; Zughaier, S.M. Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia. Metabolites 2022, 12, 771. https://doi.org/10.3390/metabo12080771
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137381903&origin=inward
URIhttp://hdl.handle.net/10576/38317
AbstractVitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways.
Languageen
PublisherMDPI
Subject25-hydroxyvitamin D
dyslipidemia
lipidomics
metabolomics
vitamin D
TitleMetabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
TypeArticle
Issue Number8
Volume Number12
ESSN2218-1989
dc.accessType Open Access


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