Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
Author | Mousa, Hanaa |
Author | Elrayess, Mohamed A. |
Author | Diboun, Ilhame |
Author | Jackson, Simon K. |
Author | Zughaier, Susu M. |
Available date | 2023-01-15T04:54:55Z |
Publication Date | 2022-08-01 |
Publication Name | Metabolites |
Identifier | http://dx.doi.org/10.3390/metabo12080771 |
Citation | Mousa, H.; Elrayess, M.A.; Diboun, I.; Jackson, S.K.; Zughaier, S.M. Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia. Metabolites 2022, 12, 771. https://doi.org/10.3390/metabo12080771 |
Abstract | Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways. |
Language | en |
Publisher | MDPI |
Subject | 25-hydroxyvitamin D dyslipidemia lipidomics metabolomics vitamin D |
Type | Article |
Issue Number | 8 |
Volume Number | 12 |
ESSN | 2218-1989 |
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