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AuthorNour K., Younis
AuthorRoumieh, Rami
AuthorBassil, Emmanuel P.
AuthorGhoubaira, Joseph A.
AuthorKobeissy, Firas
AuthorEid, Ali H.
Available date2023-01-30T06:07:50Z
Publication Date2022-11-30
Publication NameSeminars in Cancer Biology
Identifierhttp://dx.doi.org/10.1016/j.semcancer.2022.08.006
CitationYounis NK, Roumieh R, Bassil EP, Ghoubaira JA, Kobeissy F, Eid AH. Nanoparticles: Attractive tools to treat colorectal cancer. Semin Cancer Biol. 2022;86(Pt 2):1-13. doi:10.1016/j.semcancer.2022.08.006
ISSN1044579X
URIhttps://www.sciencedirect.com/science/article/pii/S1044579X22001924
URIhttp://hdl.handle.net/10576/39168
AbstractColorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This is attributed mainly to chemo- and immuno-resistance, which frequently emerge soon after treatment with conventional therapeutics. Systemic treatments are also constrained by their many undesired and serious side effects. More recently, nanomedicine has emerged as an attractive modality that can overcome issues of therapeutic resistance, improper delivery, or suboptimal targeting of tumor cells. Many nanomaterials, having already been examined in pre-clinical and clinical studies, are now considered biocompatible and relatively safe. Indeed, around 50 nano-formulations have so far been approved as diagnostic and therapeutic agents in humans. Here, in this review, we describe a set of imperative nanoparticles (NPs) involved in diagnosing and treating CRC. In particular, we discuss the theragnostic roles of quantum dots, iron oxide NPs, Polylactide-co-glycolic acid (PLGA) NPs, dendrimer NPs, carbon nanotubes, liposomes, and gold NPs. We dissect the molecular and clinical evidence supporting the use of these NPs in CRC. We also highlight their implications in targeted drug delivery as well as their anti-tumorigenic properties and effects on the cardinal hallmarks of CRC. We conclude by highlighting the notion that nanomedicine is emerging as an attractive approach to address the unmet needs in managing several diseases, including CRC.
Languageen
PublisherElsevier
SubjectNanomedicine
Nanoparticles
Theragnostics
Theranostics
Colorectal cancer
Drug delivery
TitleNanoparticles: Attractive tools to treat colorectal cancer
TypeArticle
Pagination1-13
Issue Number2
Volume Number86
ESSN1096-3650
dc.accessType Open Access


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