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المؤلفAhmad, Salma M. S.
المؤلفAl-Mansoob, Maryam
المؤلفOuhtit, Allal
تاريخ الإتاحة2023-02-13T10:51:13Z
تاريخ النشر2022
اسم المنشورFrontiers in Oncology
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.3389/fonc.2022.1038121
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40017
الملخصOur tetracycline-off-inducible CD44 expression system previously established in mouse model, revealed that activation of CD44 with its major ligand hyaluronan (HA) promoted breast cancer (BC) metastasis to the liver. To identify the mechanisms that underpin CD44-promoted BC cell invasion, microarray gene expression profiling using RNA samples from (Tet)-Off-regulated expression system of CD44s in MCF7 cells, revealed a set of upregulated genes including, nuclear sirtuin-1 (SIRT1 also known as NAD-dependent deacetylase), an enzyme that requires NAD+ as a cofactor to deacetylate several histones and transcription factors. It stimulates various oncogenic pathways promoting tumorigenesis. This data suggests that SIRT1 is a potential novel transcriptional target of CD44-downstream signaling that promote BC cell invasion/metastasis. This review will discuss the evidence supporting this hypothesis as well as the mechanisms linking SIRT1 to cell proliferation and invasion. Copyright 2022 Ahmad, Al-Mansoob and Ouhtit.
راعي المشروعQatar Foundation: Qatar UniversityThis research was funded by Qatar University Internal grant number: QUST-1-CAS2019-22 and the Qatar Foundation grant number: UREP24-117-1-027.
اللغةen
الناشرFrontiers Media S.A.
الموضوعbreast cancer
CD44
hyaluronan
metastasis
SIRT1
العنوانSIRT1, a novel transcriptional downstream target of CD44, linking its deacetylase activity to tumor cell invasion/metastasis
النوعShort Survey
رقم المجلد12
dc.accessType Open Access


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