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المؤلفSaadaoui, Imen
المؤلفBounnit, Touria
المؤلفMraiche, Fatima
المؤلفJoseph, Jensa M.
المؤلفCherif, Maroua
المؤلفAl-Jabri, Hareb
تاريخ الإتاحة2023-02-19T06:35:44Z
تاريخ النشر2022-01-01
اسم المنشورMolecular and Cellular Biochemistry
المعرّفhttp://dx.doi.org/10.1007/s11010-022-04626-7
الاقتباسSaadaoui, I., Bounnit, T., Mraiche, F. et al. Asterarcys quadricellulare (Chlorophyceae) protects H9c2 cardiomyoblasts from H2O2-induced oxidative stress. Mol Cell Biochem (2022). https://doi.org/10.1007/s11010-022-04626-7
الرقم المعياري الدولي للكتاب03008177
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85145190197&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40121
الملخصOxidative stress has recently been identified as an important mediator of cardiovascular diseases. The need to find efficient antioxidant molecules is essential in the disease’s prevention. Therefore, the present study aimed to evaluate the potential of microalgae bioactive in protecting H9c2 cardiomyoblasts from H2O2-induced oxidative stress. Four microalgal species were investigated for their antioxidant capacity. A qualitative assessment of oxidative stress in H9c2 cardiomyoblasts stained with DCFH-DA, treated with the highly active microalgae extracts, was performed. The protein expression of total caspase-3 was also examined to investigate whether the extract protects H9c2 cardimyoblasts from H2O2-induced apoptosis. High antioxidant activity was observed for the hexanoic extracts after 10 days of cultivation. Asterarcys quadricellulare exhibited the highest antioxidant capacity of 110.59 ± 1.75 mg TE g−1 dry weight and was tested against H9c2 cardiomyoblasts, which were initially subjected to H2O2-induced oxidative stress. This hexanoic extract protected against H2O2 induced oxidative stress with a similar scavenging capacity as N-Acetylcysteine. Furthermore, total caspase-3 was increased following treatment with the hexanoic extract, suggesting that A. quadricellulare also had anti-apoptotic properties. The outcome of our study highlighted the possible use of the local A. quadricellulare strain QUCCCM10 as a natural, safe, and efficient antioxidant to prevent cardiovascular diseases.
راعي المشروعOpen Access funding provided by the Qatar National Library. This report was made possible by the NPRP award [NPRP8-1087-1-207] from the Qatar National Research Fund (a member of The Qatar Foundation) and Start Up project [QUSG-CAS-CSD-14/15-9]. The statements made herein are solely the responsibility of the authors.
اللغةen
الناشرSpringer
الموضوعAntioxidant
Asterarcys quadricellulare
Cardiovascular diseases
Caspase-3
High value products
Reactive Oxygen Species
العنوانAsterarcys quadricellulare (Chlorophyceae) protects H9c2 cardiomyoblasts from H2O2-induced oxidative stress
النوعArticle
ESSN1573-4919
dc.accessType Open Access


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