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AuthorStanley, Ibeh
AuthorBakkar, Nour-Mounira Z.
AuthorAhmad, Fatima
AuthorNwaiwu, Judith
AuthorBarsa, Chloe
AuthorMekhjian, Sarine
AuthorReslan, Mohammad Amine
AuthorEid, Ali H.
AuthorHarati, Hayat
AuthorNabha, Sanaa
AuthorMechref, Yehia
AuthorEl-Yazbi, Ahmed F.
AuthorKobeissy, Firas
Available date2023-03-05T08:45:37Z
Publication Date2023-02-01
Publication NameLife Sciences
Identifierhttp://dx.doi.org/10.1016/j.lfs.2022.121316
CitationIbeh, Stanley, Nour-Mounira Z. Bakkar, Fatima Ahmad, Judith Nwaiwu, Chloe Barsa, Sarine Mekhjian, Mohammad Amine Reslan et al. "High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury." Life Sciences 314 (2023): 121316.
ISSN00243205
URIhttps://www.sciencedirect.com/science/article/pii/S0024320522010165
URIhttp://hdl.handle.net/10576/40650
AbstractAimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, there is no FDA-approved therapy available for its treatment. Thus, there has been an increasing need to understand other factors that could modulate TBI outcomes. Among the factors involved are diet and lifestyle. High-fat diets (HFD), rich in saturated fat, have been associated with adverse effects on brain health. Main methodsTo study this phenomenon, an experimental mouse model of open head injury, induced by the controlled cortical impact was used along with high-fat feeding to evaluate the impact of HFD on brain injury outcomes. Mice were fed HFD for a period of two months where several neurological, behavioral, and molecular outcomes were assessed to investigate the impact on chronic consequences of the injury 30 days post-TBI. Key findingsTwo months of HFD feeding, together with TBI, led to a notable metabolic, neurological, and behavioral impairment. HFD was associated with increased blood glucose and fat-to-lean ratio. Spatial learning and memory, as well as motor coordination, were all significantly impaired. Notably, HFD aggravated neuroinflammation, oxidative stress, and neurodegeneration. Also, cell proliferation post-TBI was repressed by HFD, which was accompanied by an increased lesion volume. SignificanceOur research indicated that chronic HFD feeding can worsen functional outcomes, predispose to neurodegeneration, and decrease brain recovery post-TBI. This sheds light on the clinical impact of HFD on TBI pathophysiology and rehabilitation as well.
SponsorThis work was funded by grants from the Science, Technology and Innovation Funding Authority to AFE (45912) and American University of Beirut Faculty of Medicine, Medical Practice Plan (AUB-FM MPP) to FK (320112). We thank the members of Dr. Ahmed El-Yazbi lab. (Nahed Mogharbil & Dr. Rana Alaaeddine) for their sincere help in conducting the cardiovascular experiments. We thank Leila Nasrallah and Yara Yehya for their help in the neurological experiments. We thank Dr. Gerry Shaw, the CEO of EnCor Biotechnology Inc. Gainesville, Fl, USA for helping us with the antibodies.
Languageen
PublisherElsevier
SubjectTraumatic brain injury
High-fat diet
Metabolic syndrome
Neuroinflammation
Neurodegeneration
Oxidative stress
TitleHigh fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
TypeArticle
Volume Number314
dc.accessType Open Access


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