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المؤلفCelsi, Fulvio
المؤلفPeri, Francesca
المؤلفCavasin, Julia
المؤلفZupin, Luisa
المؤلفCozzi, Giorgio
المؤلفBarbi, Egidio
المؤلفCrovella, Sergio
تاريخ الإتاحة2023-03-12T07:29:41Z
تاريخ النشر2023-02-01
اسم المنشورGenes
المعرّفhttp://dx.doi.org/10.3390/genes14020411
الاقتباسCelsi, F.; Peri, F.; Cavasin, J.; Zupin, L.; Cozzi, G.; Barbi, E.; Crovella, S. Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review. Genes 2023, 14, 411. https://doi.org/10.3390/genes14020411
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148914015&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40933
الملخصBackground and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, its molecular mechanisms have still not been completely unraveled. Focusing on the impact of epigenetics in the pain complex trait, we assessed the association between chronic pain and the methylation pattern of TRPA1, a key gene related to pain sensitivity. Methods: We conducted a systematic review retrieving articles from three different databases. After deduplication, 431 items were subjected to manual screening, and then 61 articles were selected and screened again. Of these, only six were maintained for meta-analysis and analyzed using specific R packages. Results: Six articles were divided into two groups (group 1: comparison of mean methylation levels between healthy subjects and patients with chronic pain; group 2: correlation between mean methylation levels and pain sensation). A non-significant mean difference was obtained from the analysis of group 1 with a value of 3.97 (95% C.I. −7.79; 15.73). Analysis of group 2 showed a high level of variability between studies (correlation = 0.35, 95% C.I. −0.12; 0.82) due to their heterogeneity (I2 = 97%, p < 0.01). Conclusions: Despite the high variability observed in the different studies analyzed, our results suggest that hypermethylation and increased pain sensitivity could be connected, possibly due to the variation of TRPA1 expression.
راعي المشروعThis work was supported by the Ministry of Health, Rome, Italy, in collaboration with the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy; grant N° RC43/22.
اللغةen
الناشرMDPI
الموضوعmethylation
pain
TRPA1
العنوانTransient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review
النوعOther
رقم العدد2
رقم المجلد14
ESSN2073-4425
dc.accessType Open Access


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