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AuthorCelsi, Fulvio
AuthorPeri, Francesca
AuthorCavasin, Julia
AuthorZupin, Luisa
AuthorCozzi, Giorgio
AuthorBarbi, Egidio
AuthorCrovella, Sergio
Available date2023-03-12T07:29:41Z
Publication Date2023-02-01
Publication NameGenes
Identifierhttp://dx.doi.org/10.3390/genes14020411
CitationCelsi, F.; Peri, F.; Cavasin, J.; Zupin, L.; Cozzi, G.; Barbi, E.; Crovella, S. Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review. Genes 2023, 14, 411. https://doi.org/10.3390/genes14020411
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148914015&origin=inward
URIhttp://hdl.handle.net/10576/40933
AbstractBackground and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, its molecular mechanisms have still not been completely unraveled. Focusing on the impact of epigenetics in the pain complex trait, we assessed the association between chronic pain and the methylation pattern of TRPA1, a key gene related to pain sensitivity. Methods: We conducted a systematic review retrieving articles from three different databases. After deduplication, 431 items were subjected to manual screening, and then 61 articles were selected and screened again. Of these, only six were maintained for meta-analysis and analyzed using specific R packages. Results: Six articles were divided into two groups (group 1: comparison of mean methylation levels between healthy subjects and patients with chronic pain; group 2: correlation between mean methylation levels and pain sensation). A non-significant mean difference was obtained from the analysis of group 1 with a value of 3.97 (95% C.I. −7.79; 15.73). Analysis of group 2 showed a high level of variability between studies (correlation = 0.35, 95% C.I. −0.12; 0.82) due to their heterogeneity (I2 = 97%, p < 0.01). Conclusions: Despite the high variability observed in the different studies analyzed, our results suggest that hypermethylation and increased pain sensitivity could be connected, possibly due to the variation of TRPA1 expression.
SponsorThis work was supported by the Ministry of Health, Rome, Italy, in collaboration with the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy; grant N° RC43/22.
Languageen
PublisherMDPI
Subjectmethylation
pain
TRPA1
TitleTransient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review
TypeOther
Issue Number2
Volume Number14
ESSN2073-4425
dc.accessType Open Access


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