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المؤلفCastellan, Martina
المؤلفZamperin, Gianpiero
المؤلفFranzoni, Giulia
المؤلفFoiani, Greta
المؤلفZorzan, Maira
المؤلفDrzewnioková, Petra
المؤلفMancin, Marzia
المؤلفBrian, Irene
المؤلفBortolami, Alessio
المؤلفPagliari, Matteo
المؤلفOggiano, Annalisa
المؤلفVascellari, Marta
المؤلفPanzarin, Valentina
المؤلفCrovella, Sergio
المؤلفMonne, Isabella
المؤلفTerregino, Calogero
المؤلفDe Benedictis, Paola
المؤلفLeopardi, Stefania
تاريخ الإتاحة2023-03-12T07:33:26Z
تاريخ النشر2023-02-03
اسم المنشورViruses
المعرّفhttp://dx.doi.org/10.3390/v15020428
الاقتباسCastellan, M.; Zamperin, G.; Franzoni, G.; Foiani, G.; Zorzan, M.; Drzewnioková, P.; Mancin, M.; Brian, I.; Bortolami, A.; Pagliari, M.; Oggiano, A.; Vascellari, M.; Panzarin, V.; Crovella, S.; Monne, I.; Terregino, C.; De Benedictis, P.; Leopardi, S. Host Response of Syrian Hamster to SARS-CoV-2 Infection including Differences with Humans and between Sexes. Viruses 2023, 15, 428. https://doi.org/10.3390/v15020428
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148975409&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40934
الملخصThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the importance of having proper tools and models to study the pathophysiology of emerging infectious diseases to test therapeutic protocols, assess changes in viral phenotypes, and evaluate the effects of viral evolution. This study provided a comprehensive characterization of the Syrian hamster (Mesocricetus auratus) as an animal model for SARS-CoV-2 infection using different approaches (description of clinical signs, viral load, receptor profiling, and host immune response) and targeting four different organs (lungs, intestine, brain, and PBMCs). Our data showed that both male and female hamsters were susceptible to the infection and developed a disease similar to the one observed in patients with COVID-19 that included moderate to severe pulmonary lesions, inflammation, and recruitment of the immune system in the lungs and at the systemic level. However, all animals recovered within 14 days without developing the severe pathology seen in humans, and none of them died. We found faint evidence for intestinal and neurological tropism associated with the absence of lesions and a minimal host response in intestines and brains, which highlighted another crucial difference with the multiorgan impairment of severe COVID-19. When comparing male and female hamsters, we observed that males sustained higher viral RNA shedding and replication in the lungs, suffered from more severe symptoms and histopathological lesions, and triggered higher pulmonary inflammation. Overall, these data confirmed the Syrian hamster as a suitable model for mild to moderate COVID-19 and reflected sex-related differences in the response against the virus observed in humans.
راعي المشروعThe study was supported by the Italian Ministry of Health trough the Strategic Project “Ricerca Corrente IZSVE 01/20 RCS”.
اللغةen
الناشرMDPI
الموضوعanimal model
histopathology
host response
immune response
SARS-CoV-2
sex
transcriptomic profile
العنوانHost Response of Syrian Hamster to SARS-CoV-2 Infection including Differences with Humans and between Sexes
النوعArticle
رقم العدد2
رقم المجلد15
ESSN1999-4915
dc.accessType Open Access


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