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AuthorMallah, Khalil
AuthorZibara, Kazem
AuthorKerbaj, Coline
AuthorEid, Ali
AuthorKhoshman, Nour
AuthorOusseily, Zahraa
AuthorKobeissy, Abir
AuthorCardon, Tristan
AuthorCizkova, Dasa
AuthorKobeissy, Firas
AuthorFournier, Isabelle
AuthorSalzet, Michel
Available date2023-03-27T07:51:01Z
Publication Date2023-01-01
Publication NameMass Spectrometry Reviews
Identifierhttp://dx.doi.org/10.1002/mas.21719
CitationMallah, K, Zibara, K, Kerbaj, C, Eid, A, Khoshman, N, Ousseily, Z, Kobeissy, A, Cardon, T, Cizkova, D, Kobeissy, F, Fournier, I, Salzet, M. Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications. Mass Spec Rev. 2023; 42: 189- 205. https://doi.org/10.1002/mas.21719
ISSN02777037
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111867443&origin=inward
URIhttp://hdl.handle.net/10576/41337
AbstractTraumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation as well as military-related practices. This type of central nervous system trauma is known to predispose patients to several neurological disorders such as Parkinson's disease, Alzheimer's disease, chronic trauamatic encephalopathy, and age-related Dementia. Recently, several proteomic and lipidomic platforms have been applied on different TBI studies to investigate TBI-related mechanisms that have broadened our understanding of its distinct neuropathological complications. In this study, we provide an updated comprehensive overview of the current knowledge and novel perspectives of the spatially resolved microproteomics and microlipidomics approaches guided by mass spectrometry imaging used in TBI studies and its applications in the neurotrauma field. In this regard, we will discuss the use of the spatially resolved microproteomics and assess the different microproteomic sampling methods such as laser capture microdissection, parafilm assisted microdissection, and liquid microjunction extraction as accurate and precise techniques in the field of neuroproteomics. Additionally, we will highlight lipid profiling applications and their prospective potentials in characterizing molecular processes involved in the field of TBI. Specifically, we will discuss the phospholipid metabolism acting as a precursor for proinflammatory molecules such as eicosanoids. Finally, we will survey the current state of spatial neuroproteomics and microproteomics applications and present the various studies highlighting their findings in these fields.
SponsorThis study was supported by grants from the Ministère de L'Education Nationale, de L'Enseignement Supérieur et de la Recherche, Université de Lille, Région Hauts de France, INSERM. K.M. received a scholarship from the Association of Scientific Orientation and Specialization (ASOS), APVV 19-0193, VEGA 1/0376/20.
Languageen
PublisherWiley
Subjectmass spectrometry imaging
spatial omics approaches
spinal cord injury
trauma brain injury
TitleNeurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
TypeArticle Review
Pagination189 - 205
Issue Number1
Volume Number42
ESSN1098-2787
dc.accessType Abstract Only


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