عرض بسيط للتسجيلة

المؤلفMarei, Hany E.
المؤلفAlthani, Asmaa
المؤلفAfifi, Nahla
المؤلفPozzoli, Giacomo
المؤلفCaceci, Thomas
المؤلفAngelini, Franco
المؤلفCenciarelli, Carlo
تاريخ الإتاحة2023-03-27T10:16:10Z
تاريخ النشر2021-09-01
اسم المنشورMolecular Biology Reports
المعرّفhttp://dx.doi.org/10.1007/s11033-021-06630-4
الاقتباسMarei, H.E., Althani, A., Afifi, N. et al. Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches. Mol Biol Rep 48, 6513–6524 (2021). https://doi.org/10.1007/s11033-021-06630-4
الرقم المعياري الدولي للكتاب03014851
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85112580652&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41351
الملخصWe give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are based on repurposing of existing therapeutic agents used against various virus infections and focused mainly on inhibition of the virus replication cycle, enhancement of innate immunity, and alleviation of CRS caused by COVID-19. Currently, more than 100 clinical trials on COVID-19 aim to provide robust evidence on the efficacy of the currently available anti-SARS-CoV-2 antiviral substances, such as the nucleotide analogue remdesivir, the antimalarial drug chloroquine, and drugs directed against docking of SARS-CoV-2 to the membrane-associated angiotensin-converting enzyme 2 (ACE2) such as transmembrane protease serine 2 (TMPRSS2). The current vaccination campaign is ongoing worldwide using different types of vaccines such as Pfizer-BioNTech and Moderna, Johnson & Johnson, Oxford-AstraZeneca, Novavax, and others with efficacy ranging from 72–95%. In March 2021 Germany limited the use of the Oxford-AstraZeneca COVID-19 vaccine to people 60 years of age and older due to concerns that it may be causing blood clots. Further study and more data are needed to confirm the safety of different available vaccines.
اللغةen
الناشرSpringer
الموضوعAntiviral agents
COVID-19 genomics
Therapeutic approach
Vaccine
العنوانPandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
النوعArticle Review
الصفحات6513-6524
رقم العدد9
رقم المجلد48
ESSN1573-4978
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة