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المؤلفUddin, Shahab
المؤلفTherachiyil, Lubna
المؤلفAnand, Anjana
المؤلفAzmi, Abdullah
المؤلفBhat, Ajaz
المؤلفKorashy, Hesham M.
تاريخ الإتاحة2023-03-29T08:34:24Z
تاريخ النشر2022-11-04
اسم المنشورF1000Research
المعرّفhttp://dx.doi.org/10.12688/f1000research.126337.1
الاقتباسTherachiyil, L., Anand, A., Azmi, A., Bhat, A., Korashy, H. M., & Uddin, S. (2022). Role of RAS signaling in ovarian cancer. F1000Research, 11, 1253.
الرقم المعياري الدولي للكتاب2046-1402
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142752374&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41416
الملخصThe RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6-65% spanning different histo-types. Normally RAS regulates several signaling pathways involved in a myriad of cellular signaling cascades mediating numerous cellular processes like cell proliferation, differentiation, invasion, and death. Aberrant activation of RAS leads to uncontrolled induction of several downstream signaling pathways such as RAF-1/MAPK (mitogen-activated protein kinase), PI3K phosphoinositide-3 kinase (PI3K)/AKT, RalGEFs, Rac/Rho, BRAF (v-Raf murine sarcoma viral oncogene homolog B), MEK1 (mitogen-activated protein kinase kinase 1), ERK (extracellular signal-regulated kinase), PKB (protein kinase B) and PKC (protein kinase C) involved in cell proliferation as well as maintenance pathways thereby driving tumorigenesis and cancer cell propagation. KRAS mutation is also known to be a biomarker for poor outcome and chemoresistance in OC. As a malignancy with several histotypes showing varying histopathological characteristics, we focus on reviewing recent literature showcasing the involvement of oncogenic RAS in mediating carcinogenesis and chemoresistance in OC and its subtypes.
اللغةen
الناشرTaylor & Francis
الموضوعCell signaling
Mutation
Oncogene
Ovarian cancers
RAS
العنوانRole of RAS signaling in ovarian cancer
النوعArticle
رقم المجلد11
ESSN2046-1402
dc.accessType Open Access


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