Role of RAS signaling in ovarian cancer
المؤلف | Uddin, Shahab |
المؤلف | Therachiyil, Lubna |
المؤلف | Anand, Anjana |
المؤلف | Azmi, Abdullah |
المؤلف | Bhat, Ajaz |
المؤلف | Korashy, Hesham M. |
تاريخ الإتاحة | 2023-03-29T08:34:24Z |
تاريخ النشر | 2022-11-04 |
اسم المنشور | F1000Research |
المعرّف | http://dx.doi.org/10.12688/f1000research.126337.1 |
الاقتباس | Therachiyil, L., Anand, A., Azmi, A., Bhat, A., Korashy, H. M., & Uddin, S. (2022). Role of RAS signaling in ovarian cancer. F1000Research, 11, 1253. |
الرقم المعياري الدولي للكتاب | 2046-1402 |
الملخص | The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and 61, ranges from 6-65% spanning different histo-types. Normally RAS regulates several signaling pathways involved in a myriad of cellular signaling cascades mediating numerous cellular processes like cell proliferation, differentiation, invasion, and death. Aberrant activation of RAS leads to uncontrolled induction of several downstream signaling pathways such as RAF-1/MAPK (mitogen-activated protein kinase), PI3K phosphoinositide-3 kinase (PI3K)/AKT, RalGEFs, Rac/Rho, BRAF (v-Raf murine sarcoma viral oncogene homolog B), MEK1 (mitogen-activated protein kinase kinase 1), ERK (extracellular signal-regulated kinase), PKB (protein kinase B) and PKC (protein kinase C) involved in cell proliferation as well as maintenance pathways thereby driving tumorigenesis and cancer cell propagation. KRAS mutation is also known to be a biomarker for poor outcome and chemoresistance in OC. As a malignancy with several histotypes showing varying histopathological characteristics, we focus on reviewing recent literature showcasing the involvement of oncogenic RAS in mediating carcinogenesis and chemoresistance in OC and its subtypes. |
اللغة | en |
الناشر | Taylor & Francis |
الموضوع | Cell signaling Mutation Oncogene Ovarian cancers RAS |
النوع | Article |
رقم المجلد | 11 |
ESSN | 2046-1402 |
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