Browsing College of Medicine by Author "Xue, Mingzhan"
Now showing items 1-7 of 7
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Dicarbonyl stress, protein glycation and the unfolded protein response
Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Springer , 2021 , Article Review)The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ... -
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
Ashour, Amal; Xue, Mingzhan; Al-Motawa, Maryam; Thornalley, Paul J.; Rabbani, Naila ( BMJ Publishing Group , 2020 , Article)Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ... -
Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes
Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ... -
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response
Xue, Mingzhan; Irshad, Zehra; Rabbani, Naila; Thornalley, Paul J. ( Elsevier B.V. , 2024 , Article)The unfolded protein response (UPR) detects increased misfolded proteins and activates protein refolding, protein degradation and inflammatory responses. UPR sensors in the endoplasmic reticulum, IRE1α and PERK, bind and ... -
Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inflammation
Rabbani, Naila; Xue, Mingzhan; Weickert, Martin O.; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)The dietary supplement, trans-resveratrol and hesperetin combination (tRES-HESP), induces expression of glyoxalase 1, countering the accumulation of reactive dicarbonyl glycating agent, methylglyoxal (MG), in overweight ... -
Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
Alhujaily, Muhanad; Abbas, Hafsa; Xue, Mingzhan; de la Fuente, Alberto; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ... -
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
Al-Motawa, Maryam S.; Abbas, Hafsa; Wijten, Patrick; de la Fuente, Alberto; Xue, Mingzhan; Rabbani, Naila; Thornalley, Paul J.... more authors ... less authors ( Frontiers Media , 2020 , Article)The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...