Browsing College of Medicine by Author "Calver, Brian L."
Now showing items 1-3 of 3
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Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket
Angelos, Thanassoulas; Vassilakopoulou, Vyronia; Calver, Brian L.; Buntwal, Luke; Smith, Adrian; Lai, Christopher; Kontogianni, Iris; Livaniou, Evangelia; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( Elsevier , 2023 , Article)Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and ... -
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLC?
Nomikos, Michail; Stamatiadis, Panagiotis; Sanders, Jessica R.; Beck, Konrad; Calver, Brian L.; Buntwal, Luke; Lofty, Morgan; Sideratou, Zili; Swann, Karl; Lai, F. Anthony... more authors ... less authors ( Portland Press Ltd , 2017 , Article)Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus that evokes intracellular calcium (Ca2+) oscillations that are essential for the initiation of egg activation during mammalian ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
Nomikos, Michail; Thanassoulas, Angelos; Beck, Konrad; Theodoridou, Maria; Kew, Jasmine; Kashir, Junaid; Calver, Brian L.; Matthews , Emily; Rizkallah, Pierre; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ...