Browsing College of Medicine by Title
Now showing items 965-984 of 1358
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Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection
( Wiley-Blackwell , 2024 , Article)Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been ... -
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats
( Elsevier B.V. , 2017 , Article)The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected ... -
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence applications and further questions
( Elsevier Ltd , 2018 , Article)Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of characteristic calcium (Ca2+) oscillations in mammals. This characteristic pattern of Ca2+ release is induced in a species-specific ... -
Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment.
( wiley , 2020 , Article)Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to ... -
Physical activity in pregnancy prevents gestational diabetes: A meta-analysis
( Elsevier , 2020 , Article)AimsThe effectiveness of physical activity (PA) programs for prevention of gestational diabetes (GDM) lacks conclusive evidence. The aim of this study was to generate clear evidence regarding the effectiveness of physical ... -
Physicians should build their own machine-learning models
( Elsevier , 2024 , Other)Yosra Mekki suggests that doctors should have the ability to develop their own machine-learning models. She proposes an approach with the "spotlight" on physicians, to create user-friendly frameworks that allow doctors to ... -
Physiological Intracranial Calcifications in Children A computed tomography-based study
( Sultan Qaboos University , 2023 , Article)Objectives: This study aimed to examined the frequency of physiological intracranial calcifications (PICs) in paediatric population using computed tomography (CT). Methods: The brain CT scans of consecutive patients (age ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ... -
Pilot Evaluation of the “Practice Educators’ Academy” Preceptor Development Program for Continuing Health Professional Education Programs in Qatar
( Qatar University Press , 2021 , Poster)"The Practice Educators' Academy Program" is an innovative educational intervention developed following a preceptor-focused needs assessment. This study evaluated the program's effect on self-efficacy and knowledge amongst ... -
A Pilot Randomized Controlled Trial of De Novo Belatacept-based Immunosuppression After Lung Transplantation.
( Wolters Kluwer Health , 2024 , Article)Chronic lung allograft dysfunction (CLAD) is the leading cause of death beyond the first year after lung transplantation. The development of donor-specific antibodies (DSA) is a recognized risk factor for CLAD. Based on ... -
Platelet thromboxane inhibition by low-dose aspirin in polycythemia vera: Ex vivo and in vivo measurements and in silico simulation
( Wiley , 2022 , Article)Low-dose aspirin is currently recommended for patients with polycythemia vera (PV), a myeloproliferative neoplasm with increased risk of arterial and venous thromboses. Based on aspirin pharmacodynamics in essential ... -
Platelet–Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Histological structure of thrombi is a strong determinant of the outcome of vascular recanalization therapy, the only treatment option for acute ischemic stroke (AIS) patients. A total of 21 AIS patients from this study ... -
Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease
( Elsevier , 2022 , Article)Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ... -
Policy and legislation for the treatment of mental health and substance use disorders in Qatar
( Elsevier , 2023 , Article)There is a marked paucity of publications on the policy and legislation of mental health, and substance use disorders in the public domain in Qatar. Qatar National Vision provides a framework for national strategies and ... -
Polypharmacy and drug interactions amongst cirrhotic patients discharged from a tertiary center: Results from a national quality improvement audit
( Elsevier , 2020 , Article)Background and Study AimsAuditing of polypharmacy is particularly essential in patients with cirrhosis because of the crucial role of liver in drug metabolism. The aim of this study was to audit the drug prescribed in this ... -
Population Preferences for Primary Care Models for Hypertension in Karnataka, India
( American Medical Association , 2023 , Article)IMPORTANCE Hypertension contributes to more than 1.6 million deaths annually in India, with many individuals being unaware they have the condition or receiving inadequate treatment. Policy initiatives to strengthen disease ... -
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ... -
Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-α, IL-1β, IL-10 and IL-17A
( Public Library of Science , 2021 , Article)Biomarkers play a pivotal role in the management of rheumatoid arthritis (RA) by facilitating early diagnosis and ‘treat to the target.’ However, no gold standard biomarker has been identified for monitoring the disease ... -
Potential causes of male and female infertility in Qatar
( Elsevier , 2020 , Article Review)A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the ...