College of Medicine: المرسلات الحديثة
السجلات المعروضة 701 -- 720 من 1448
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Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
( Frontiers Media , 2023 , Article)Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ... -
Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm
( MDPI , 2023 , Article)Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation ... -
Epac as a tractable therapeutic target
( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Dicarbonyl stress, protein glycation and the unfolded protein response
( Springer , 2021 , Article Review)The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ... -
Efficiency and productivity of health systems in prevention and control of non-communicable diseases in China, 2008–2015
( Springer , 2021 , Article)This article examines the health system performance impact of China’s new round of healthcare reform adopted in 2009. Specifically, we evaluated productivity and efficiency of health production pre- and post-reform period, ... -
COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity
( Springer , 2022 , Article Review)Currently, health authorities around the world are struggling to limit the spread of COVID-19. Since the beginning of the pandemic, social distancing has been the most important strategy used by most countries to control ... -
Correction to: Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment (Cancer Immunology, Immunotherapy, (2021), 70, 8, (2103-2121), 10.1007/s00262-020-02842-y)
( Springer , 2021 , Other)in the hypoxic tumor microenvironment, written by Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian and Eyad Elkord, was originally published electronically on the publisher’s internet portal on 03 ... -
Correction to: 68Ga-PSMA PET/CT tumour intensity pre-operatively predicts adverse pathological outcomes and progression-free survival in localised prostate cancer
( Springer , 2021 , Other)Figure 2b is incorrect in the original paper, the correct Fig. 2 is shown below: (Figure presented.). -
Oral Vaccine Delivery: The Coming Age of Particulate Vaccines to Elicit Mucosal Immunity
( Springer , 2020 , Book chapter)With the evolution of different challenging diseases, there is an urgent need of vaccine development against them to save millions of lives around the world. Particlulate delivery system plays an important role by acting ... -
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
( Wiley , 2022 , Article Review)The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ... -
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
( Wiley , 2021 , Article)Background: Tangible efforts have been made to identify biomarkers for Parkinson's disease (PD) diagnosis and progression, with α-synuclein (α-syn) related biomarkers being at the forefront. Objectives: The objectives of ... -
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
( Wiley , 2023 , Article Review)Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ... -
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ... -
Therapeutic effects of statins on osteoarthritis: A review
( Wiley , 2022 , Article Review)Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ... -
Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries
( Wiley , 2020 , Article)Aims: Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and ... -
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value
( Wiley , 2021 , Article)We firstly identified 48 kDa molecular form of the unconventional myosin 1c (p48/Myo1C), and isolated it from blood serum of multiple sclerosis patients. The amount of p48/Myo1C in human blood serum correlated with some ... -
Novel Post-translational Modifications in Human Serum Albumin
( Bentham , 2022 , Article)Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ... -
Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer
( Springer , 2021 , Article)DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ... -
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
( Wiley , 2020 , Article)Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ... -
Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease
( American Medical Association , 2022 , Article)Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ...