College of Medicine: Recent submissions
Now showing items 1061-1080 of 1448
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Occupational exposure to HIV among nurses at a major tertiary hospital: Reporting and utilization of post-exposure prophylaxis; A cross-sectional study in the Western Cape, South Africa
( Public Library of Science , 2020 , Article)© 2020 Kabotho, Chivese. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... -
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
( Elsevier , 2021 , Article)Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ... -
A proposed framework to guide evidence synthesis practice for meta-analysis with zero-events studies
( Elsevier , 2021 , Article)ObjectiveIn evidence synthesis practice, researchers often face the problem of how to deal with zero-events. Inappropriately dealing with zero-events studies may lead to research waste and mislead healthcare practice. We ... -
Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel.
( Wiley , 2021 , Article)The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ... -
Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases
( Frontiers Media , 2020 , Article)© Copyright © 2020 Marei, Emara, Elsaied, Nasrallah, Chivese, Al-Romaihi, Althani, Al Thani, Farag and Yassine. Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly ... -
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
( MDPI , 2021 , Article)Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ... -
Estimation of sex from the metacarpal dimensions at the nutrient foramen in white South Africans
( Taylor and Francis , 2020 , Article)© 2020 Australian Academy of Forensic Sciences. Sex estimation is important in both forensic and archaeological cases and requires a variety of bones and measurements to obtain accurate estimates. Discriminant function ... -
Avoidability of drug-induced liver injury (DILI) in an elderly hospital cohort with cases assessed for causality by the updated RUCAM score
( BMC , 2020 , Article)© 2020 The Author(s). Background: Drug-induced liver injury (DILI) represents an increasing morbidity in the general population, but more so in the elderly cohort of patients. Despite this, the concept of its prevention ... -
Accuracies of discriminant function equations for sex estimation using long bones of upper extremities
( Springer , 2020 , Article)© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. One of the scopes of practice of forensic anthropologists is the estimation of sex from skeletal remains. As a result, population-specific discriminant function ... -
Laplace approximation, penalized quasi-likelihood, and adaptive Gauss-Hermite quadrature for generalized linear mixed models: Towards meta-analysis of binary outcome with sparse data
( BMC , 2020 , Article)© 2020 The Author(s). Background: In meta-analyses of a binary outcome, double zero events in some studies cause a critical methodology problem. The generalized linear mixed model (GLMM) has been proposed as a valid ... -
Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study
( Elsevier , 2021 , Article)An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine. We evaluated the methodological issues of these SRMAs. A protocol was developed in advance. Three ... -
Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events
( Elsevier , 2020 , Article Review)ObjectivesMeta-analyses of rare events often generate unstable results, and selective reporting of the results may mislead the health care decision. Developing a synthesis plan for rare events in protocol may help to ... -
Arcsine-based transformations for meta-analysis of proportions: Pros, cons, and alternatives
( Wiley Open Access , 2020 , Article)© 2020 The Authors. Health Science Reports published by Wiley Periodicals LLC. Meta-analyses have been increasingly used to synthesize proportions (eg, disease prevalence) from multiple studies in recent years. Arcsine-based ... -
Association between response rates and monetary incentives in sample study: a systematic review and meta-analysis.
( BMJ Publishing Group , 2020 , Article)To investigate the effect of monetary incentive and the dose-response relationship of participants' response rates in surveys. Three databases were searched for randomised controlled trials (RCTs) that investigated the ... -
Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy: A case report.
( Lippincott, Williams & Wilkins , 2021 , Article)Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. Most pediatric PHEOs are functional tumors, and clinical manifestations are related to catecholamine hypersecretion ... -
Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered
( Elsevier , 2021 , Article)Background and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the ... -
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
( American Heart Association , 2020 , Article)N/A -
The MethodologicAl STandards for Epidemiological Research (MASTER) scale demonstrated a unified framework for bias assessment
( Elsevier , 2021 , Article)Objective: This paper presents a unified framework for assessment of the methodological quality of analytic study designs. Study Design and Setting: A systematic review of 393 methodological quality assessment tools that ... -
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
( Nature Research , 2020 , Article)Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ... -
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
( American Heart Association , 2020 , Article)OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...