College of Medicine: Recent submissions
Now showing items 1101-1120 of 1448
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Congenital microcephaly-linked CDK5RAP2 affects eye development
( Wiley , 2020 , Article)Biallelic mutations in the cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2 cause autosomal recessive primary microcephaly type 3 (MCPH3). MCPH is characterized by intellectual disability and ... -
A new method for synthesizing test accuracy data outperformed the bivariate method
( Elsevier , 2020 , Article)This paper outlines the development of a new method (split component synthesis; SCS) for meta-analysis of diagnostic accuracy studies and assesses its performance against the commonly used bivariate random effects model. ... -
Advances in Cardiovascular Biomarker Discovery.
( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
A Successful Treatment of Encapsulating Peritoneal Sclerosis in an Adolescent Boy on Long-term Peritoneal Dialysis: A Case Report.
( First Faculty of Medicine Charles University , 2020 , Article)Encapsulating peritoneal sclerosis (EPS) is a rare life-threatening complication associated with peritoneal dialysis (PD). EPS is characterized by progressive fibrosis and sclerosis of the peritoneum, with the formation ... -
Assessment of the Role of Serum 25-Hydroxy Vitamin D Level on Coronary Heart Disease Risk With Stratification Among Patients With Type 2 Diabetes Mellitus
( SAGE Publications , 2020 , Article)© The Author(s) 2020. We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were ... -
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
( Elsevier , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP), the most debilitating complication of diabetes mellitus, is resistant to current therapy. The pathogenesis of DPNP is still elusive, but several mechanisms have been proposed ... -
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
( Mary Ann Liebert , 2020 , Article)Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including ... -
Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling
( Dove Medical Press , 2020 , Article)© 2020 Alotaibi et al. Introduction: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known medicinal and protective properties against cytotoxicity. This study ... -
Immunofluorescence Staining of Paraffin Sections Step by Step.
( Frontiers Media , 2020 , Article)Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be found in the literature and the websites of commercial antibody ... -
Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar
( Elsevier , 2020 , Article)ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors ... -
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLC?
( Portland Press Ltd , 2017 , Article)Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus that evokes intracellular calcium (Ca2+) oscillations that are essential for the initiation of egg activation during mammalian ... -
Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study
( Elsevier , 2020 , Article)ObjectiveTesticular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors that may be predict ... -
Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix.
( Lippincott, Williams & Wilkins , 2020 , Article)Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially ... -
Islam and Mental Disorders of the Older Adults: Religious Text, Belief System and Caregiving Practices.
( Springer , 2020 , Article)This paper illustrates the impact of Islamic religious texts on dementia care in the Middle East. It examines how old age and older adults mental disorders are framed in the Quran and Hadith, and how these texts are ... -
Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice
( Elsevier , 2020 , Article)Background and Objectives In clinical trials, the relative risk or risk ratio (RR) is a mainstay of reporting of the effect magnitude for an intervention. The RR is the ratio of the probability of an outcome in an ... -
A Biomarker Based Severity Progression Indicator for COVID-19: The Kuwait Prognosis Indicator Score.
( Taylor and Francis , 2020 , Article)COVID-19 is a worldwide pandemic that is mild in most patients but can result in a pneumonia like illness with progression to acute respiratory distress syndrome and death. Predicting the disease severity at time of diagnosis ... -
Global incidence of caesarean deliveries on maternal request: a systematic review and meta-regression.
( Wiley , 2020 , Article)Caesarean delivery on maternal request (CDMR) is considered a significant contributor to the unprecedented increase in caesarean deliveries (CDs) for nonclinical reasons. Current literature lacks a reliable assessment of ... -
Physical activity in pregnancy prevents gestational diabetes: A meta-analysis
( Elsevier , 2020 , Article)AimsThe effectiveness of physical activity (PA) programs for prevention of gestational diabetes (GDM) lacks conclusive evidence. The aim of this study was to generate clear evidence regarding the effectiveness of physical ... -
68 Ga-PSMA PET/CT tumour intensity pre-operatively predicts adverse pathological outcomes and progression-free survival in localised prostate cancer
( Springer , 2020 , Article)© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) improves prostate cancer staging. Intraprostatic PSMA intensity may ... -
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
( Elsevier , 2020 , Article)ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ...