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AuthorBadran, Saif
AuthorDoi, Suhail
AuthorHammouda, Atalla
AuthorMusa, Omran
AuthorHabib, Abdella
Available date2023-05-16T08:18:06Z
Publication Date2023-03-22
Publication NameBiomolecules and Biomedicine
Identifierhttp://dx.doi.org/10.17305/bb.2022.8807
CitationBadran, S., Doi, S., Hammouda, A., Musa, O., & Habib, A. (2023). Validation of Doi’s weighted average glucose as a measure of post-load glucose excursion for clinical use. Biomolecules and Biomedicine.‏
URIhttp://hdl.handle.net/10576/42779
AbstractIn this study, we examined the performance of a novel index of glucose excursion (Doi’s weighted average glucose [dwAG]) in relation to the conventional measure of area under the oral glucose tolerance test (A-GTT) and the homeostatic model assessment for insulin sensitivity (HOMA-S) and pancreatic beta cell function (HOMA-B). A cross-sectional comparison of the new index was conducted using 66 oral glucose tolerance tests (GTTs) performed at different follow-up times among 27 participants who had undergone surgical subcutaneous fat removal (SSFR). Comparisons across categories were made using box plots and the Kruskal-Wallis one-way ANOVA on ranks. Passing-Bablok regression was used to compare the dwAG against the conventional A-GTT. The Passing-Bablok regression model suggested a cutoff for normality for the A-GTT of 15.14 mmol/L·2h-1 compared to the dwAG’s suggested threshold of 6.8 mmol/L. For every 1 mmol/L·2h-1 increase in A-GTT, the dwAG value increased by 0.473 mmol/L. The glucose area under the curve correlated well with the four defined dwAG categories, with at least one of the categories having a different median A-GTT value (KW Chi2 = 52.8 [df = 3], P < 0.001). The HOMA-S tertiles were also associated with significantly different levels of glucose excursion measured through both the dwAG value (KW Chi2 = 11.4 [df = 2], P = 0.003) and A-GTT measure (KW Chi2 = 13.1 [df = 2], P = 0.001). It is concluded that the dwAG value and categories serve as a simple and accurate tool that can be used for interpreting glucose homeostasis across clinical settings.
Languageen
PublisherBiomolecules and Biomedicine
SubjectDoi’s weighted average glucose
TitleValidation of Doi's weighted average glucose as a measure of post-load glucose excursion for clinical use.
TypeArticle
dc.accessType Abstract Only


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