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AuthorAlsayed, Reem Khaled M.E.
AuthorSheikhan, Khalid Sultan A.M.
AuthorAlam, Majid Ali
AuthorBuddenkotte, Jorg
AuthorSteinhoff, Martin
AuthorUddin, Shahab
AuthorAhmad, Aamir
Available date2023-05-16T09:07:34Z
Publication Date2023
Publication NameSeminars in Cancer Biology
ResourceScopus
ISSN1044579X
URIhttp://dx.doi.org/10.1016/j.semcancer.2023.04.005
URIhttp://hdl.handle.net/10576/42810
AbstractCancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with cancer stemness, thus presenting as attractive targets for cancer therapy. The growing interest in non-coding RNAs (ncRNAs) in the recent years has provided further insight into the mechanisms by which TFs influence cancer stem cell characteristics. There is evidence for a direct regulation of TFs by ncRNAs, such as, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) as well as circular RNAs (circRNAs), and vice versa. Additionally, the TF-ncRNAs regulations are often indirect, involving ncRNA-target genes or the sponging of other ncRNA species by individual ncRNAs. The information is rapidly evolving and this review provides a comprehensive review of TF-ncRNAs interactions with implications on cancer stemness and in response to therapies. Such knowledge will help uncover the many levels of tight regulations that control cancer stemness, providing novel opportunities and targets for therapy in the process.
SponsorOpen Access funding for this article has been provided by the Qatar National Library.
Languageen
PublisherElsevier
SubjectCancer stem cells
LncRNAs
MiRNAs
NF-κB
Non-coding RNAs
STAT-3
TitleEpigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
TypeArticle Review
Pagination74-83
Volume Number92
dc.accessType Open Access


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