College of Pharmacy: Recent submissions
Now showing items 321-340 of 1314
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Genetic polymorphism effect on warfarin–rifampin interaction: A case report and review of literature
( Dove Medical Press , 2021 , Article)Warfarin–rifampin interaction has been reported since the 1970s. Due to rifampin’s strong induction of CYP2C9, most cases could not attain the target international normalized ratio (INR) despite warfarin dose escalation. ... -
COVID-19 vaccination: From interesting agent to the patient
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. ... -
Managing Pain in Low Resource Settings: Healthcare Professionals’ Knowledge, Attitude and Practice Regarding Pain Management in Western Nepal
( Dove Medical Press Ltd , 2022 , Article)Background: Pain is a public health problem and affects millions of people globally. Effective pain management is possible through comprehensive pain management guidelines, adequate facilities, and trained healthcare ... -
Long-acting injectable antipsychotics: A systematic review of their non-systemic adverse effect profile
( Dove Medical Press , 2021 , Article)Introduction: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or ... -
Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats
( Taylor and Francis Inc. , 2020 , Article)Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed AmpB formulations. The goal of the ... -
Soliciting the Oral Route as a Logical Approach to Managing Colon Cancer
( Frontiers Media S.A. , 2021 , Article)According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2018, colon cancer (CC) is the third most common cancer in men and second in women worldwide (Bray et al., 2018). Approximately 1.8 million new colon ... -
Solid Dispersion Formulations by FDM 3D Printing—A Review
( MDPI , 2022 , Article)Additive manufacturing (AM) is revolutionizing the way medicines are designed, manufactured, and utilized. Perhaps, AM appears to be ideal for the fit-for-purpose manufacturing of medicines in contrast to the several ... -
Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer
( Springer Science and Business Media Deutschland GmbH , 2022 , Article)There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe ... -
The types and pattern of use of mobile health applications among the general population: A cross-sectional study from Selangor, Malaysia
( Dove Medical Press , 2021 , Article)Purpose: The aims of this study are to explore the types and patterns of use of health mobile apps among pharmacy clients in Selangor, Malaysia, and to explore the users’ experiences and views regarding the benefits of and ... -
Genetic and non-genetic factors impact on inr normalization in preprocedural warfarin management
( Dove Medical Press , 2021 , Article)Background: Annually, 10% of warfarin patients will likely need to stop warfarin prior to elective surgery to achieve a baseline international normalization ratio (INR) level (INR ≤ 1.2) at the time of the procedure. This ... -
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin
( Taylor and Francis Ltd. , 2021 , Article)Tocotrienol (TRF) ethosomes were developed and evaluated in vitro for potential transdermal delivery against melanoma. The optimised TRF ethosomal size ranged between 64.9 ± 2.2 nm to 79.6 ± 3.9 nm and zeta potential (ZP) ... -
Lyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil
( MDPI AG , 2021 , Article)Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or ... -
Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
( Elsevier , 2021 , Article)Protein misfolding and aggregation can be induced by a wide variety of factors, such as dominant disease-associated mutations, changes in the environmental conditions (pH, temperature, ionic strength, protein concentration, ... -
Improved bioavailability of poorly soluble drugs through gastrointestinal muco-adhesion of lipid nanoparticles
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve ... -
The role of amyloids in Alzheimer's and Parkinson's diseases
( Elsevier , 2021 , Article)With varying clinical symptoms, most neurodegenerative diseases are associated with abnormal loss of neurons. They share the same common pathogenic mechanisms involving misfolding and aggregation, and these visible aggregates ... -
Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ... -
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ... -
Clinical and humanistic outcomes of community pharmacy‐based healthcare interventions regarding medication use in older adults: A systematic review and meta‐analysis
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)This review and meta‐analysis aimed to determine the clinical and humanistic outcomes of community pharmacy‐based interventions on medication‐related problems of older adults at the primary care level. We identified ... -
Pharmacies in the Airport Ecosystem and How They Serve Travelers' Health and Medicines Need: Findings and Implications for the Future.
( Dove Press , 2022 , Article)Pharmacists at airport pharmacies could offer essential health services for air travelers. Consequently, this study aimed to explore the type of professional services, the types of medicines at airport pharmacies and ... -
An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels
( Thieme , 2022 , Article)This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug ...
