Air-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility
Author | Augustine, Robin |
Author | Kalva, Sumama Nuthana |
Author | Dalvi, Yogesh B. |
Author | Varghese, Ruby |
Author | Chandran, Maneesh |
Author | Hasan, Anwarul |
Available date | 2023-06-08T10:30:05Z |
Publication Date | 2023 |
Publication Name | Colloids and Surfaces B: Biointerfaces |
Resource | Scopus |
Abstract | The development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. The widely used nanofiber fabrication methods like electrospinning are time consuming and the obtained nanofibrous scaffolds are generally consist of compactly packed fibers, which affect proper cell penetration. On the other hand, air-jet spinning is an upcoming, less explored alternative approach for generating loosely arranged nanofibrous scaffolds within short time. However, air-jet spun scaffolds show inferior mechanical properties due to loosely organized fibers. Herein, we report the fabrication and detailed characterization of polycaprolactone (PCL) tissue engineering scaffolds loaded with diamond nanosheets (DNS) by air-jet spinning. Our results showed that the inclusion of DNS could improve the mechanical strength of the scaffolds. In vitro biocompatibility, and in vivo implantation studies demonstrated that PCL-DNS scaffolds are highly biocompatible and are suitable for tissue engineering applications. Our studies showed that mammalian cells can proliferate well in the presence of PCL-DNS scaffolds and the nanocomposite scaffolds implanted in rats did not show any considerable adverse effects. Overall, the findings show that the developed novel air-jet spun PCL-DNS nanocomposite scaffolds can be used as cell supportive scaffolds for various tissue engineering applications. |
Sponsor | This article was made possible by the NPRP12S-0310-190276 grant funded by the Qatar National Research Fund (a part of the Qatar Foundation). We also acknowledge the support provided by the Center for Advanced Materials (CAM) and Central Laboratories Unit (CLU), Qatar University, Qatar. |
Language | en |
Publisher | Elsevier |
Subject | Air-jet spinning Nanodiamond Polycaprolactone Tissue engineering |
Type | Article |
Volume Number | 221 |
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Biomedical Research Center Research [727 items ]
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Mechanical & Industrial Engineering [1342 items ]