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AuthorAugustine, Robin
AuthorKalva, Sumama Nuthana
AuthorDalvi, Yogesh B.
AuthorVarghese, Ruby
AuthorChandran, Maneesh
AuthorHasan, Anwarul
Available date2023-06-08T10:30:05Z
Publication Date2023
Publication NameColloids and Surfaces B: Biointerfaces
ResourceScopus
URIhttp://dx.doi.org/10.1016/j.colsurfb.2022.112958
URIhttp://hdl.handle.net/10576/44229
AbstractThe development of highly porous cell supportive polymeric scaffolds with sufficient mechanical strength has always been a challenging task in tissue engineering. The widely used nanofiber fabrication methods like electrospinning are time consuming and the obtained nanofibrous scaffolds are generally consist of compactly packed fibers, which affect proper cell penetration. On the other hand, air-jet spinning is an upcoming, less explored alternative approach for generating loosely arranged nanofibrous scaffolds within short time. However, air-jet spun scaffolds show inferior mechanical properties due to loosely organized fibers. Herein, we report the fabrication and detailed characterization of polycaprolactone (PCL) tissue engineering scaffolds loaded with diamond nanosheets (DNS) by air-jet spinning. Our results showed that the inclusion of DNS could improve the mechanical strength of the scaffolds. In vitro biocompatibility, and in vivo implantation studies demonstrated that PCL-DNS scaffolds are highly biocompatible and are suitable for tissue engineering applications. Our studies showed that mammalian cells can proliferate well in the presence of PCL-DNS scaffolds and the nanocomposite scaffolds implanted in rats did not show any considerable adverse effects. Overall, the findings show that the developed novel air-jet spun PCL-DNS nanocomposite scaffolds can be used as cell supportive scaffolds for various tissue engineering applications.
SponsorThis article was made possible by the NPRP12S-0310-190276 grant funded by the Qatar National Research Fund (a part of the Qatar Foundation). We also acknowledge the support provided by the Center for Advanced Materials (CAM) and Central Laboratories Unit (CLU), Qatar University, Qatar.
Languageen
PublisherElsevier
SubjectAir-jet spinning
Nanodiamond
Polycaprolactone
Tissue engineering
TitleAir-jet spun tissue engineering scaffolds incorporated with diamond nanosheets with improved mechanical strength and biocompatibility
TypeArticle
Volume Number221
dc.accessType Abstract Only


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