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AuthorFlynn, Kiley
AuthorMahmoud, Nouf N.
AuthorSharifi, Shahriar
AuthorGould, Lisa J.
AuthorMahmoudi, Morteza
Available date2023-06-18T10:23:25Z
Publication Date2023-04-19
Publication NameACS Pharmacology and Translational Science
Identifierhttp://dx.doi.org/10.1021/acsptsci.3c00030
CitationFlynn, K., Mahmoud, N. N., Sharifi, S., Gould, L. J., & Mahmoudi, M. (2023). Chronic Wound Healing Models. ACS Pharmacology & Translational Science, 6(5), 783-801.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85154529968&origin=inward
URIhttp://hdl.handle.net/10576/44514
AbstractIn this paper, we review and analyze the commonly available wound healing models reported in the literature and discuss their advantages and issues, considering their relevance and translational potential to humans. Our analysis includes different in vitro and in silico as well as in vivo models and experimental techniques. We further explore the new technologies in the study of wound healing to provide an all encompassing review of the most efficient ways to proceed with wound healing experiments. We revealed that there is not one model of wound healing that is superior and can give translatable results to human research. Rather, there are many different models that have specific uses for studying certain processes or stages of wound healing. Our analysis suggests that when performing an experiment to assess stages of wound healing or different therapies to enhance healing, one must consider not only the species that will be used but also the type of model and how this can best replicate the physiology or pathophysiology in humans.
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases - grant No. DK131417
Languageen
PublisherAmerican Chemical Society (ACS)
Subjectanimal wound model
chronic wounds
in vitro wound model
in vivo wound model
pathophysiology
wound healing
TitleChronic Wound Healing Models
TypeArticle
Pagination783-801
ESSN2575-9108
dc.accessType Abstract Only


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