Show simple item record

AuthorPalakkott, Abdul Rasheed
AuthorAlneyadi, Aysha
AuthorMuhammad, Khalid
AuthorEid, Ali Hussein
AuthorAmiri, Khaled M.A.
AuthorAkli Ayoub, Mohammed
AuthorIratni, Rabah
Available date2023-06-19T07:02:35Z
Publication Date2023-04-01
Publication NameVaccines
Identifierhttp://dx.doi.org/10.3390/vaccines11040768
CitationPalakkott, A.R.; Alneyadi, A.; Muhammad, K.; Eid, A.H.; Amiri, K.M.A.; Akli Ayoub, M.; Iratni, R. The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling. Vaccines 2023, 11, 768. https://doi.org/10.3390/vaccines11040768
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85153775790&origin=inward
URIhttp://hdl.handle.net/10576/44546
AbstractThe coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-CoV-2 uses its envelope glycoprotein, the spike S protein, to infect the target cells in the lungs via binding with their transmembrane receptor, the angiotensin-converting enzyme 2 (ACE2). Here, we wanted to investigate if other molecular targets and pathways may be used by SARS-CoV-2. We investigated the possibility of the spike 1 S protein and its receptor-binding domain (RBD) to target the epidermal growth factor receptor (EGFR) and its downstream signaling pathway in vitro using the lung cancer cell line (A549 cells). Protein expression and phosphorylation were examined upon cell treatment with the recombinant full spike 1 S protein or RBD. We demonstrate for the first time the activation of EGFR by the Spike 1 protein associated with the phosphorylation of the canonical Extracellular signal-regulated kinase1/2 (ERK1/2) and AKT kinases and an increase in survivin expression controlling the survival pathway. Our study suggests the putative implication of EGFR and its related signaling pathways in SARS-CoV-2 infectivity and COVID-19 pathology. This may open new perspectives in the treatment of COVID-19 patients by targeting EGFR.
Languageen
PublisherMDPI
Subjectcancer
COVID-19
EGFR
hijacking
SARS-CoV-2
signaling
Spike
TitleThe SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
TypeArticle
Issue Number4
Volume Number11
ESSN2076-393X
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record