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AuthorYassin, Aksam
AuthorAlwani, Mustafa
AuthorAl-Zoubi, Raed M.
AuthorAboumarzouk, Omar M.
AuthorTalib, Raidh
AuthorNettleship, Joanne
AuthorKelly, Daniel
AuthorAlbaba, Bassam
Available date2023-06-19T08:45:30Z
Publication Date2023-05-06
Publication NameInternational Urology and Nephrology
Identifierhttp://dx.doi.org/10.1007/s11255-023-03602-4
CitationYassin, A., Alwani, M., Al-Zoubi, R. M., Aboumarzouk, O. M., Talib, R., Nettleship, J., ... & Albaba, B. (2023). Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size. International Urology and Nephrology, 1-10.
ISSN0301-1623
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85158139845&origin=inward
URIhttp://hdl.handle.net/10576/44563
AbstractBackground: Functional hypogonadism is a condition in which some, but not all, older men have low testosterone levels. Rather than chronological age per se, the causality of hypogonadism includes obesity and impaired general health (e.g., metabolic syndrome). An association between testosterone deficiency and lower urinary tract symptoms (LUTS) has been reported, yet due to prostate safety concerns, men with severe LUTS (IPSS score > 19) have invariably been excluded from entering testosterone trials. Irrespective, exogenous testosterone has not been demonstrated to cause de novo or worsen mild to moderate LUTS. Objective: This study investigated whether long-term testosterone therapy (TTh) could have a protective effect on improving the symptoms of LUTS in hypogonadal men. However, the exact mechanism by which testosterone exerts is beneficial effect remains uncertain. Patients and methods: In this study 321 hypogonadal patients with an average age of 58.9 ± 9.52 years received testosterone undecanoate in 12-week intervals for 12 years. One hundred and forty-seven of these males had the testosterone treatment interrupted for a mean of 16.9 months before it was resumed. Total testosterone, International Prostate Symptom Scale (IPSS), post-voiding residual bladder volume and aging male symptoms (AMS) were measured over the study period. Results: Prior to TTh interruption, it was observed that testosterone stimulation improved the men’s IPSS, AMS and post-voiding residual bladder volume, while their prostate volume significantly increased. During the TTh interruption, there was a significant worsening in these parameters, although the increase in prostate volume continued. When TTh was resumed, these effects were reversed, implying that hypogonadism may require lifelong treatment.
Languageen
PublisherSpringer Nature
SubjectBenign prostate hyperplasia
Hypogonadism
LUTS
Prostate cancer
Testosterone
TitleVoiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size
TypeArticle
Pagination1-10
ESSN1573-2584
dc.accessType Open Access


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