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AuthorAlaa Ahmed, Abbas
AuthorAbdulkader, Hadil Adnan
AuthorGiordo, Roberta
AuthorAshour, Hossam M.
AuthorErre, Gian Luca
AuthorPintus, Gianfranco
AuthorZayed, Hatem
Available date2023-06-21T04:53:06Z
Publication Date2023-04-30
Publication NameInternational Journal of Biological Macromolecules
Identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2023.123783
ISSN01418130
URIhttps://www.sciencedirect.com/science/article/pii/S0141813023006773
URIhttp://hdl.handle.net/10576/44621
AbstractCircular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can play a role in the pathogenesis of several diseases. Rheumatic diseases are a varied group of autoimmune and inflammatory disorders affecting mainly the musculoskeletal system. Notably, circRNAs, which are essential immune system gene modulators, are strongly linked to the occurrence and progression of autoimmune disorders. Here, we present and discuss the current findings concerning the roles, implications and theragnostic potentials of circRNAs in common rheumatic diseases, including ankylosing spondylitis (AS), osteoarthritis (OA), osteoporosis (OP), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Crohn's disease (CD), and gout. This review aims to provide new insights to support the development of novel diagnostic and therapeutic strategies for these disabling diseases.
SponsorThis work has been made possible thanks to grants from (Progetto Fondazione di Sardegna - bando 2022-2023 and FAR2020-Pintus) to GP
Languageen
PublisherElsevier
SubjectcircRNAs
Rheumatic diseases
Therapeutic potential
Diagnostic potential
Circular RNAs
TitleImplications and theragnostic potentials of circular RNAs in rheumatic diseases
TypeArticle Review
Volume Number235
dc.accessType Open Access


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