Implications and theragnostic potentials of circular RNAs in rheumatic diseases
Author | Alaa Ahmed, Abbas |
Author | Abdulkader, Hadil Adnan |
Author | Giordo, Roberta |
Author | Ashour, Hossam M. |
Author | Erre, Gian Luca |
Author | Pintus, Gianfranco |
Author | Zayed, Hatem |
Available date | 2023-06-21T04:53:06Z |
Publication Date | 2023-04-30 |
Publication Name | International Journal of Biological Macromolecules |
Identifier | http://dx.doi.org/10.1016/j.ijbiomac.2023.123783 |
ISSN | 01418130 |
Abstract | Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can play a role in the pathogenesis of several diseases. Rheumatic diseases are a varied group of autoimmune and inflammatory disorders affecting mainly the musculoskeletal system. Notably, circRNAs, which are essential immune system gene modulators, are strongly linked to the occurrence and progression of autoimmune disorders. Here, we present and discuss the current findings concerning the roles, implications and theragnostic potentials of circRNAs in common rheumatic diseases, including ankylosing spondylitis (AS), osteoarthritis (OA), osteoporosis (OP), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Crohn's disease (CD), and gout. This review aims to provide new insights to support the development of novel diagnostic and therapeutic strategies for these disabling diseases. |
Sponsor | This work has been made possible thanks to grants from (Progetto Fondazione di Sardegna - bando 2022-2023 and FAR2020-Pintus) to GP |
Language | en |
Publisher | Elsevier |
Subject | circRNAs Rheumatic diseases Therapeutic potential Diagnostic potential Circular RNAs |
Type | Article Review |
Volume Number | 235 |
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Biomedical Sciences [692 items ]