Biomedical Research Center Research
Recent Submissions
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BNT162b2 Versus mRNA-1273 Vaccines: Comparative Analysis of Long-Term Protection Against SARS-CoV-2 Infection and Severe COVID-19 in Qatar
( Wiley , 2024 , Article)Background: This study provides a head-to-head comparison of the protection provided by the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection and against severe COVID-19, covering primary series and third ... -
Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods.
( Springer Nature , 2024 , Article)Architect-HIV Ag/Ab combo chemiluminescence assay is globally recognized for its sensitivity but has a notable false-positive rate. In this study, we aim to evaluate the performance of a new cost-effective screening ... -
Alterations in Choline Metabolism in Non-Obese Individuals with Insulin Resistance and Type 2 Diabetes Mellitus
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The prevalence of non-obese individuals with insulin resistance (IR) and type 2 diabetes (T2D) is increasing worldwide. This study investigates the metabolic signature of phospholipid-associated metabolites in non-obese ... -
Identification of KSR2 Variants in Pediatric Patients with Severe Early-Onset Obesity from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 ... -
Experimental analysis of free-standing and substrate-constrained Ga-doped ZnO nanostructured thermoelectric films
( Elsevier , 2024 , Article)Developing thermoelectric films without substrates—free-standing films—eliminates substrate-induced effects on performance and meets the flexibility requirements of emerging wearable thermoelectric applications. This study ... -
Senolytics in diseases: killing to survive
( Elsevier , 2023 , Book chapter)Since the discovery of cellular senescence in 1961, numerous studies have investigated the role of senescent cells in the pathogenesis of many chronic diseases. Cellular senescence, defined by irreversible cell cycle arrest, ... -
Expression analysis and mapping of Viral—Host Protein interactions of Poxviridae suggests a lead candidate molecule targeting Mpox
( Springer Nature , 2024 , Article)Background: Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable ... -
Evaluation of Efficacy of Surface Coated versus Encapsulated Influenza Antigens in Mannose–Chitosan Nanoparticle-Based Intranasal Vaccine in Swine
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)This study focuses on the development and characterization of an intranasal vaccine platform using adjuvanted nanoparticulate delivery of swine influenza A virus (SwIAV). The vaccine employed whole inactivated H1N2 SwIAV ... -
Revolutionizing Cardiovascular Health with Nano Encapsulated Omega-3 Fatty Acids: A Nano-Solution Approach
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) offer diverse health benefits, such as supporting cardiovascular health, improving cognitive function, promoting joint and musculoskeletal health, and contributing to healthy ... -
Editorial: Revisiting mouse models of traumatic brain injuries: a focus on intracellular mechanisms
( Frontiers Media , 2024 , Article)Traumatic brain injury (TBI) continues to be a critical health condition, especially for the newly born, the elderly, and victims of motor vehicle accidents, sports concussions, war blasts, etc. Due to the extremely ... -
Deciphering metabolomics and lipidomics landscape in zebrafish hypertrophic cardiomyopathy model
( Springer Nature , 2024 , Article)To elucidate the lipidomic and metabolomic alterations associated with hypertrophic cardiomyopathy (HCM) pathogenesis, we utilized cmybpc3-/- zebrafish model. Fatty acid profiling revealed variability of 10 fatty acids ... -
Molecular screening of phytocompounds targeting the interface between influenza A NS1 and TRIM25 to enhance host immune responses
( Elsevier , 2024 , Article)BackgroundInfluenza A virus causes severe respiratory illnesses, especially in developing nations where most child deaths under 5 occur due to lower respiratory tract infections. The RIG-I protein acts as a sensor for viral ... -
Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
( John Wiley & Sons , 2024 , Article)Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca2+)-binding sensor that plays a vital role in many cellular processes by binding and regulating the activity of over 300 protein targets. In cardiac muscle, CaM ... -
Joint Effects of Exercise and Ramadan Fasting on Telomere Length: Implications for Cellular Aging
( MDPI , 2024 , Article)Aging is a fundamental biological process that progressively impairs the functionality of the bodily systems, leading to an increased risk of diseases. Telomere length is one of the most often used biomarkers of aging. ... -
The impact of intermittent fasting during Ramadan on psychomotor and cognitive skills in adolescent athletes
( Frontiers Media SA , 2024 , Article)Introduction: Intermittent fasting (IF) represents a dietary intervention similar to caloric restriction, characterized by the strategic limitation of food consumption. Among the diverse array of practices for IF, Ramadan ... -
S1.P170 A terpenoids-enriched fraction of Inula viscosa: its chemical composition and anti-cancerous effects against human lung cancer cells
(2024 , Conference Paper)Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has limited therapeutic options. Effects of Ziziphus nummularia against TNBC have not been investigated yet. An ethanolic extract of ... -
(423) ARE E-CIGARETTES SAFER THAN COMBUSTIBLE TOBACCO ON HUMAN TYPE II ALVEOLAR CELLS AND MESENCHYMAL STEM CELLS?
(2024 , Conference Paper)Electronic cigarettes (e-cigarettes) are promoted as safer alternatives to combustible cigarettes. However, the health burden and effects of their long-term use remain unidentified. This study evaluates the extent and ... -
Review on the visible light photocatalysis for the decomposition of ciprofloxacin, norfloxacin, tetracyclines, and sulfonamides antibiotics in wastewater
( MDPI , 2021 , Article Review)Antibiotics are chemical compounds that are used to kill or prevent bacterial growth. They are used in different fields, such as the medical field, agriculture, and veterinary. Antibiotics end up in wastewater, which causes ... -
Synergistic effect of concentration and annealing on structural, mechanical, and room-temperature thermoelectric properties of n-type Ga-doped ZnO films
( Elsevier , 2024 , Article)The development of Ga-doped Zinc Oxide (GZO) films from nontoxic, abundant elements using a cost-effective and scalable approach is crucial for the profitability and sustainability of thermoelectric applications. Challenges ... -
Statistical methods and resources for biomarker discovery using metabolomics
( Springer Nature , 2023 , Article)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ...
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