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AuthorZolezzi, Monica
AuthorAbouelhassan, Rawan
AuthorEltorki, Yassin
AuthorHaddad, Peter M.
AuthorNoorizadeh, Mahtab
Available date2023-07-31T10:21:12Z
Publication Date2021-05-05
Publication NameNeuropsychiatric Disease and Treatment
Identifierhttp://dx.doi.org/10.2147/NDT.S309768
CitationZolezzi, M., Abouelhassan, R., Eltorki, Y., Haddad, P. M., & Noorizadeh, M. (2021). Long-acting injectable antipsychotics: a systematic review of their non-systemic adverse effect profile. Neuropsychiatric Disease and Treatment, 1917-1926.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108664669&origin=inward
URIhttp://hdl.handle.net/10576/46433
AbstractIntroduction: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or injection site adverse effect profile. As such, this study aims to review and evaluate all evidence reporting injection site adverse effects with LAI antipsychotics. Methods: An electronic search was systematically conducted through four databases (PubMed, Embase, SCOPUS, Cochrane) in order to identify studies investigating injection-site reactions associated with LAI antipsychotics. Unpublished studies such as conference proceedings and clinical trial registries were also searched. The search was limited to literature published in English without year limits. Results: Of a total of 189 citations that were identified from the electronic database search, 12 were selected for inclusion in this review. Various injection site reactions were reported in these studies, including pain, bleeding, and swelling. Overall, the studies reported a low incidence of these injection site reactions. Only a minority of the included articles compared injection site reactions between different LAI antipsychotics. Conclusion: Injection site pain was the most commonly reported injection site adverse effect across all articles reviewed. The low incidence of injection site adverse effects associated with LAI antipsychotics indicates that these formulations appear to be well tolerated by patients. More head-to-head trials comparing second generation LAI antipsy-chotics are needed.
Languageen
PublisherDove Medical Press
SubjectDepot antipsychotics
Injection site adverse effects
Intramuscular preparations
TitleLong-acting injectable antipsychotics: A systematic review of their non-systemic adverse effect profile
TypeArticle
Pagination1917-1926
Volume Number17
ESSN1178-2021
dc.accessType Open Access


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