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المؤلفFardoun, Manal
المؤلفDehaini, Hassan
المؤلفShaito, Abdallah
المؤلفMesmar, Joelle
المؤلفEl-Yazbi, Ahmed
المؤلفBadran, Adnan
المؤلفBeydoun, Elias
المؤلفEid, Ali H.
تاريخ الإتاحة2023-08-28T09:09:50Z
تاريخ النشر2020
اسم المنشورVascular Pharmacology
المصدرScopus
الرقم المعياري الدولي للكتاب15371891
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.vph.2019.106600
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46842
الملخصCardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The implication of estrogen in this disease has been extensively studied. While the vast majority of published research argue for a cardioprotective role of estrogen in vascular inflammation such as in atherosclerosis, the role of estrogen in hypertension remains far from being resolved. The vasorelaxant effect of estrogen has already been well-established. However, emerging evidence supports a vasoconstrictive potential of this hormone. It has been proposed that the microenvironment dictates the effect of estrogen-induced type 1 nitric oxide synthase-1 (nNOS) on vasotone. Indeed, depending on nNOS product, nitric oxide or superoxide, estrogen can induce vasodilation or vasoconstriction, respectively. In this review, we discuss the evidence supporting the vasorelaxant effects of estrogen, and the molecular players involved. Furthermore, we shed light on recent reports revealing a vasoconstrictive role of estrogen, and speculate on the underlying signaling pathways. In addition, we identify certain factors that can account for the discrepant estrogenic effects. This review emphasizes a yin-yang role of estrogen in regulating blood pressure. 2019
راعي المشروعThis publication was made possible by an MPP Fund (#320133) from the American University of Beirut-Faculty of Medicine to Ali Eid and The National Center for Scientific Research (CNRS) to Manal Fardoun.
اللغةen
الناشرElsevier
الموضوع17β-estradiol
Blood pressure
Estrogen
Hypertension
Vascular smooth muscle cells
Vasoconstriction
Vasodilation
العنوانThe hypertensive potential of estrogen: An untold story
النوعArticle Review
رقم المجلد124
dc.accessType Abstract Only


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