Common and Rare Genetic Variants Associated With Alzheimer's Disease
المؤلف | Marei, Hany E. |
المؤلف | Althani, Asmaa |
المؤلف | Suhonen, Jaana |
المؤلف | El Zowalaty, Mohamed E. |
المؤلف | Albanna, Mohammad A. |
المؤلف | Cenciarelli, Carlo |
المؤلف | Wang, Tengfei |
المؤلف | Caceci, Thomas |
تاريخ الإتاحة | 2016-07-20T11:08:01Z |
تاريخ النشر | 2016-07-01 |
اسم المنشور | Journal of Cellular Physiology |
الاقتباس | Marei, H. E., Althani, A., Suhonen, J., El Zowalaty, M. E., Albanna, M. A., Cenciarelli, C., Wang, T. and Caceci, T. (2016), Common and Rare Genetic Variants Associated With Alzheimer's Disease. J. Cell. Physiol., 231: 1432–1437. doi: 10.1002/jcp.25225 |
الرقم المعياري الدولي للكتاب | 0021-9541(print) |
الرقم المعياري الدولي للكتاب | 1097-4652(online) |
الملخص | Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome-wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD-related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets. |
راعي المشروع | BRC, QU |
اللغة | en |
الناشر | WILEY PERIODICALS, INC. |
الموضوع | Genetic varients Alzheimer's disease rare varients common varients |
النوع | Article |
الصفحات | 1432–1437 |
رقم العدد | 7 |
رقم المجلد | 231 |
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