Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies.
Date
2015-10-06Author
El Zowalaty, Mohamed E.Al Thani, Asmaa A.
Webster, Thomas J.
El Zowalaty, Ahmed E.
Schweizer, Herbert P.
Nasrallah, Gheyath K.
Marei, Hany E.
Ashour, Hossam M.
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Metadata
Show full item recordAbstract
Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections. The abundant data on the increased resistance to antipseudomonal agents support the need for global action. There is a paucity of new classes of antibiotics active against P. aeruginosa. Here, we discuss recent antibacterial resistance profiles and mechanisms of resistance by P. aeruginosa. We also review future potential methods for controlling antibiotic-resistant bacteria, such as phage therapy, nanotechnology and antipseudomonal vaccines.
DOI/handle
http://dx.doi.org/10.2217/fmb.15.48http://dx.doi.org/10.2217/fmb.15.48
http://hdl.handle.net/10576/4688
Collections
- Biomedical Research Center Research [738 items ]
- Health Sciences-CAS (pre 2016) [151 items ]