Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
المؤلف | Fardoun, Manal Muin |
المؤلف | Maaliki, Dina |
المؤلف | Halabi, Nabil |
المؤلف | Iratni, Rabah |
المؤلف | Bitto, Alessandra |
المؤلف | Baydoun, Elias |
المؤلف | Eid, Ali H. |
تاريخ الإتاحة | 2023-08-29T10:21:48Z |
تاريخ النشر | 2020 |
اسم المنشور | Clinical Science |
المصدر | Scopus |
الرقم المعياري الدولي للكتاب | 1435221 |
الملخص | Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values. |
راعي المشروع | This publication was made possible by an MPP fund [grant number 320133] and a Farouk Jabre Award from the American University of Beirut (to Ali H. Eid). |
اللغة | en |
الناشر | Portland Press Ltd |
الموضوع | adipose tissue inflammation atherosclerosis cardiovascular disease flavonoids obesity |
النوع | Article Review |
الصفحات | 1403-1432 |
رقم العدد | 12 |
رقم المجلد | 134 |
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