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AuthorAlsalem, Mohammad
AuthorAldossary, Sara A.
AuthorHaddad, Mansour
AuthorAltarifi, Ahmad
AuthorKalbouneh, Heba
AuthorAzab, Belal
AuthorMustafa, Ayman G.
AuthorJaffal, Sahar M.
AuthorEl-Salem, Khalid
Available date2023-09-03T06:44:18Z
Publication Date2020
Publication NameNeuroReport
ResourceScopus
ISSN9594965
URIhttp://dx.doi.org/10.1097/WNR.0000000000001485
URIhttp://hdl.handle.net/10576/47169
AbstractTransient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different inflammatory mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. The aim of the present study is to investigate the desensitization of TRPV1 receptor by nonpungent agonists and to determine how bradykinin and prostaglandin E2 receptors (EP3 and EP4) modulate the resensitization of TRPV1 receptor after being desensitized by nonpungent agonists. Tail flick test was used to investigate capsaicin-induced thermal hyperalgesia and the desensitization of TRPV1 by the nonpungent agonists (olvanil and arvanil) in male BALB/c mice weighed (22-25 g). Resensitization of TRPV1 by bradykinin and the role of prostaglandin receptors in mediating sensitization of TRPV1 were also investigated. Intraplantar injection of capsaicin (0.3 µg) produced a robust thermal hyperalgesia in mice, while olvanil (0.3 µg) or arvanil (0.3 µg) produced no hyperalgesia, emphasizing their lack of pungency. Olvanil and arvanil significantly attenuated capsaicin-induced thermal hyperalgesia in mice. Bradykinin significantly reversed the desensitizing effects of arvanil, but not olvanil. EP4 but not EP3 receptors mediate the sensitization of TRPV1 By bradykinin in vivo. The present study provides evidence for a novel signaling pathway through which bradykinin can regulate the TRPV1 ion channel function via EP4 receptor.
Languageen
PublisherLippincott Williams and Wilkins
Subjectarvanil
bradykinin
EP3
EP4
olvanil
Transient receptor potential vanilloid type-1
TitleThe desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin
TypeArticle
Pagination781-786
dc.accessType Abstract Only


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